L-menthol-based eutectic solvents: Characterization and application in the removal of drugs from water

Bergua, Fernando; Castro, Miguel; Embid, José Muñoz; Lafuente, Carlos; Artal, Manuela

doi:10.1016/j.molliq.2022.118754

Cited by 25 publications

(17 citation statements)

References 75 publications

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“…Experimentally determined densities (ρ) of the DESs Men:DA, Thy:DA, and Thy:Men at four, four, and nine different compositions, respectively, in the temperature range 293.15 to 363.15 K are reported in Table . Previously reported density values of these DESs (only at selected compositions) mostly under ambient conditions (at 298.15 K) ,,,− are summarized in Table and reveal excellent agreement with our measured values. Irrespective of the temperature, constituents, and the composition, the densities of all the investigated DESs are lower than that of water under ambient conditions.…”

Section: Resultssupporting

confidence: 89%

“…The relative standard uncertainty in η of the solvents for the entire temperature range is estimated to be 0.02 mPa·s. Table , Figure , and Figure summarize the observed values of density and dynamic viscosity of the selected DESs measured by us as well as those available in the literature. ,,,− It is important to state here that the values experimentally measured by us were found to be in good agreement with those reported in the literature. The slight disparities in the measurement values may arise due to differences in the water content present or the presence of impurities.…”

Section: Methodssupporting

confidence: 80%

“…From the various DESs under investigation, L(−)-menthol/ n -decanoic acid (Men:DA) and thymol/ n -decanoic acid (Thy:DA) mixtures were found to form clear and stable room temperature liquids in the compositions ranging from 0.33:0.67 to 0.67:0.33 mole fraction ratios, while thymol/L(−)-menthol (Thy:Men) mixtures were stable in the wider composition range of 0.17:0.83 to 0.83:0.17 mole fraction ratios. The stability of these DESs was previously reported in the literature. ,,− …”

Section: Methodsmentioning

confidence: 55%

“…Dynamic viscosity at 298.15 K of some of the DESs investigated here are reported earlier; and our measured values are in good agreement with those (Table ). ,,,− A comparison of the η of the DESs investigated here with the reported η of other DESs reveals the η of Men:DA, Thy:DA, and Thy:Men DESs to be relatively lower in comparison. For example, viscosity is much higher for a urea-based type III DES with choline chloride in 1:2 (ChCl/urea) molar ratio (∼750 mPa·s at 298.15 K) and type I DES with ZnCl 2 in 1:3.5 (ZnCl 2 /urea) molar ratio (∼11340 mPa·s at 298.15 K) .…”

Section: Resultsmentioning

confidence: 68%

“… a Standard uncertainties u are u ( x ) = 0.00 5 , u ( T ) = 0.05 K, u (ρ) = 0.001 g·cm –3 , u r (η) = 0.02 mPa·s; DES compositions are given in mole fraction ratios. b Reference . c Reference . d Reference . e Reference . f All physical parameters at 313.15 K. g Density and dynamic viscosity are measured at 293.15 K. h Reference . i Reference . …”

Section: Methodsmentioning

confidence: 99%

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Water Miscibility, Surface Tension, Density, and Dynamic Viscosity of Hydrophobic Deep Eutectic Solvents Composed of Capric Acid, Menthol, and Thymol

2022

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Deep eutectic solvents (DESs) are rapidly emerging as environmentally benign and viable alternatives not only to common organic solvents but to relatively toxic ionic liquids as well. By judicious selection of the constituents and subsequent variation in their composition, the key physicochemical properties of the DESs can be easily tailored for a specific application. Impact of variation in constituents as well as their composition on important physical properties of natural DESs (NADESs) prepared using a common fatty acid n-decanoic acid (DA) and two naturally occurring monoterpenoids, thymol (Thy) and L(−)-menthol (Men), is assessed. Specifically, water miscibility, surface tension, density, and dynamic viscosity of 17 different DESs of three combinations of constituents, Men:DA, Thy:DA, and Thy:Men in four, four, and nine compositions, respectively, are measured. The water intake by the DESs under ambient conditions varies from 0.6 to 2.7 mol·kg–1 offering a means to gauge their hydrophobicity. Water miscibility is relatively lower for Men:DA DESs and higher for Thy:DA DESs. Surface tension values are within 28.37 mN·m–1 to 31.14 mN·m–1 under ambient conditions; they are higher for the DESs with the Thy constituent and vary systematically with DES composition. The densities of all the DESs are lower than that of water and decrease linearly with increasing temperature. While density does not vary with composition for Men:DA, it is found to increase linearly with an increase in Thy mole fraction for Thy:DA and Thy:Men DESs. The dynamic viscosity of the DESs are relatively lower as compared to the common tetralkylammonium salt- and metal salt-based DESs, and exhibit strong constituent and composition dependence. Rather than the Arrhenius-type expression, the temperature-dependence of the dynamic viscosity better conforms to the Vogel–Fulcher–Tammann (VFT) model with activation energy of the viscous flow varying systematically with the constituent and composition. Reported physical properties and their dependence on constituents/composition of the NADESs will enhance their utility and help establish them as novel alternate media in science and technology.

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