L’intestin moyen de drosophile

Andriatsilavo, Maheva; Gervais, Louis; Fons, Clara; Bardin, Allison J.

doi:10.1051/medsci/2013291016

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…It is noted that ISC-specific Notch activation is associated with the suppression of ISC proliferation. The differentiation process is triggered by Notch in EBs and is mediated by the Delta protein from ISCs [ 138 , 139 ]. According to Hou SX and colleagues, Hey, da, and Smr are negative regulators of Notch that affect ISC-to-EC differentiation [ 42 ].…”

Section: Reviewmentioning

confidence: 99%

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

Liu

Jin

2017

Cell Commun Signal

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The gastrointestinal tract serves as a fast-renewing model for unraveling the multifaceted molecular mechanisms underlying remarkably rapid cell renewal, which is exclusively fueled by a small number of long-lived stem cells and their progeny. Stem cell activity is the best-characterized aspect of mucosal homeostasis in mitotically active tissues, and the dysregulation of regenerative capacity is a hallmark of epithelial immune defects. This dysregulation is frequently associated with pathologies ranging from chronic enteritis to malignancies in humans. Application of the adult Drosophila gastrointestinal tract model in current and future studies to analyze the immuno-physiological aspects of epithelial defense strategies, including stem cell behavior and re-epithelialization, will be necessary to improve our general understanding of stem cell participation in epithelial turnover. In this review, which describes exciting observations obtained from the adult Drosophila gastrointestinal tract, we summarize a remarkable series of recent findings in the literature to decipher the molecular mechanisms through which stem cells respond to nonsterile environments.

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Section: Reviewmentioning

confidence: 99%

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

Liu

Jin

2017

Cell Commun Signal

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La niche hématopoïétique de la drosophile

2014

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(Figure 1). Cependant, bien que le concept de niche ait été proposé dès 1978 [7], les relations fonctionnelles entre niches et CSH restent mal connues. La découverte d'une « niche hématopoïétique » chez la drosophile ouvre de nouvelles possibilités pour étudier in vivo comment le microenvironnement contrôlant l'autorenouvellement et la différenciation des progéniteurs hématopoïétiques est lui-même régulé. Avantages du modèle drosophile pour des études in vivoLa majorité des gènes qui régulent l'hématopoïèse sont conservés au cours de l'évolution, de la drosophile aux vertébrés [8]. La redondance fonctionnelle entre gènes/protéines d'une même famille étant beaucoup moins importante chez la drosophile, ce modèle facilite les analyses fonctionnelles in vivo [9]. La drosophile présente aussi un temps de génération court et offre une panoplie de techniques génétiques sophistiquées. Enfin, alors que chez les vertébrés l'héma-topoïèse adulte se situe dans la moelle osseuse, elle a lieu chez la drosophile dans un organe facilement accessible et manipulable in vivo : la glande lymphatique.

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La complexité insoupçonnée du tractus digestif de la drosophile

Osman

Buchon

2014

Med Sci (Paris)

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L’intestin moyen de drosophile

Cited by 3 publications

References 59 publications

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

La niche hématopoïétique de la drosophile

La complexité insoupçonnée du tractus digestif de la drosophile

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