L'infection extrapulmonaire à Mycoplasma pneumoniae

Garnier, Jean Marc; Noël, G.; Retornaz, K.; Blanc, Pascal; Minodier, P.

doi:10.1016/s0929-693x(05)80002-8

Cited by 26 publications

(21 citation statements)

References 56 publications

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“…Nevertheless, M. hyopneumoniae has already been reisolated from brains of infected pigs (9). Other mycoplasmas with predilection for the respiratory tract, M. pneumoniae in human (11,53) and M. gallisepticum in poultry (34), are able to cross the mucosal barrier and spread in the host. Nevertheless, the persistence observed in this study cannot be explained by dissemination of mycoplasmas in inner organs, as this phenomenon seems to be transitory: no mycoplasma could be reisolated from inner organs at the end of the studies.…”

Section: Discussionmentioning

confidence: 99%

Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

Carrou

Laurentie

Kobisch

et al. 2006

Antimicrob Agents Chemother

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The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser803Phe and Asp843Asn), and one point mutation was observed just behind the QRDR of ParC (Ala1163Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC.Mycoplasma hyopneumoniae is one of the primary pathogens associated with the porcine respiratory disease complex, one of the most common and economically important diseases for swine producers worldwide (43). M. hyopneumoniae is the etiological agent of enzootic pneumonia in swine, a chronic respiratory disease characterized by high morbidity and low mortality rates (15). The principal clinical but not constant sign is a chronic cough. Mycoplasmal pneumonia is located mainly in the anterior lobes of the lung. In the acute phase of the disease, catarrhal pneumonia is observed, with exudates in the airways. The bronchial and mediastinal lymph nodes are often enlarged. In the chronic stage of the disease, recovering lesions, consisting of fissures of collapsed alveoli adjoining areas of alveolar emphysema, are observed (26). M. hyopneumoniae is a very contagious bacterium and may be transmitted via direct contact between pigs (43) or via environment (14, 48).In vitro, M. hyopneumoniae is susceptible to various antibiotics, including fluoroquinolones, tetracyclines, spiramycin, and tiamulin (17,18,19,25,42,49). However, although antibiotic treatments are usually able to control the disease (49), persistence is observed under field conditions (43) and experimental infections (16,25)....

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Section: Discussionmentioning

confidence: 99%

Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

Carrou

Laurentie

Kobisch

et al. 2006

Antimicrob Agents Chemother

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“…Tous droits réservés. mais ont également été décrits méningites aseptiques, cérébellites, encéphalomyélites aiguës disséminées (ADEM), myélites aiguës transverses, polynévrites, syndromes de Guillain-Barré, atteintes des nerfs crâniens, accidents vasculaires cérébraux (AVC), états psychotiques aigus et myosites [6]. Nous rapportons 9 cas pédiatriques de formes neurologiques diverses liées à M. pneumoniae et décrivons leurs caractéristiques sémiologiques, les étapes ayant conduit au diagnostic et la thérapeutique proposée.…”

Section: Résuméunclassified

Formes neurologiques des infections à Mycoplasma pneumoniae : à propos de neuf cas pédiatriques

Roussel

Poulat

Romaszko

et al. 2015

Archives de Pédiatrie

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“…Minimum CSF-IgG level was observed in cases with aseptic meningitis without encephalitis (P value: 0.03). Many studies defined the convulsion as common presentation sign in M .pneumonia induced encephalitis (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…Extra pulmonary manifestations, with or without respiratory involvement reported (2). Cardiac involvement; hematologic, skin, renal, gastro-intestinal, osteo-articular, neurologic, and other manifestations have also been reported in literature.…”

Section: Introductionmentioning

confidence: 86%

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Mycoplasma pneumonia in Cerebrospinal Fluids of Febrile Children With Neurologic Manifestations: A Cross Sectional Study: Tehran, Iran

Noorbakhsh

Zarabi

Shamshiri

et al. 2013

Jundishapur J Microbiol

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Background:The clinical spectrum of Mycoplasma pneumoniae CNS diseases had a wide range. Encephalitis and meningoencephalitis are the most frequent neurological manifestations, but cases of optic neuritis, transverse myelitis, Guillain-Barré syndrome (GBS), etc. have been reported Objectives: To determine the role of M. pneumonia (using PCR and serologically test) in Cerebro Spinal Fluid (CSF) in febrile children with neurologic manifestations (in comparison with normal CSF). Materials and Methods:This cross sectional study was done in pediatric wards of Rasoul hospital in Tehran between 2008 -2010 upon 55 febrile cases with neurological signs and 10 controls with normal CSF (simple febrile seizure). The CSF samples tested for M. pneumonia DNA (PCR); and Immune Globulin G (IgG) level. Chi square values < 0.05 were considered statistically significant. Results: Positive PCR found in 1 case with Guillan Barre syndrome (1/53; 2%) and none of controls; IgG-CSF level (Cut off 0.0025) had significant difference between cases and controls (Kappa = 0.27, P Value = 0.000). The lowest and highest IgG level observed in aseptic meningitis, and convulsive cases respectively. 73% sensitivity; 90% specificity; 100% Variance (PPV); 28.8% Net Present Value (NPV) determined for IgG-CSF test. Conclusions: Even, very low amount of CSF-IgG with good specificity (90%); could differentiate cases and controls (P = 0.000). The CSF-IgG test (sensitivity 70%, NPV 28.8%) was weak for ruling out the M. pneumonia in cases. positive PCR was rare (2%) in CSF of cases and controls but is more reliable for diagnosing the recent M. pneumonia infection. We prefer to assay the CSF for both serology and PCR in highly suspicious cases. Anti-microbial or immune modulating therapies had possible benefits.

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L'infection extrapulmonaire à Mycoplasma pneumoniae

Cited by 26 publications

References 56 publications

Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

Formes neurologiques des infections à Mycoplasma pneumoniae : à propos de neuf cas pédiatriques

Mycoplasma pneumonia in Cerebrospinal Fluids of Febrile Children With Neurologic Manifestations: A Cross Sectional Study: Tehran, Iran

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