L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos

Pekmezekmek, Ayper Boğa; Emre, Mustafa; Tunç, Erdal; Sertdemır, Yaşar

doi:10.1007/s11356-020-10155-x

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…And L-glutamic acid is also an important secondary source of carbon and nitrogen for the re-synthesis of pyrimidines and hydrazines (Wu, 2013). Previous report had also proved that L-glutamic acid exhibited potential protective effects on embryos, and this might be related to the activation of mitogen-activated protein kinase (MAPK) pathway and cell proliferation (Boga Pekmezekmek et al, 2020). Another report had also proved that an elevated level of asparagine was significantly correlated with a clinical pregnancy and live birth (Brison et al, 2004).…”

Section: Metabolism Of Alanine Aspartic Acid and Glutamic Acidmentioning

confidence: 99%

Metabonomics Study on the Infertility Treated With Zishen Yutai Pills Combined With In Vitro Fertilization-embryo Transfer

Ning²,

Wei

et al. 2021

Front. Pharmacol.

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Zishen Yutai Pills (ZYP) is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction, including prevention of miscarriage, increase of pregnancy rate during in vitro fertilization-embryo transfer (IVF-ET). The plasma of patients was collected from a clinical trial, namely, “Effect of Traditional Chinese Medicine vs placebo on live births among women undergoing in vitro fertilization, a multi-center randomized controlled trial.” Plasma samples were analyzed with metabonomics method. UPLC-MS technology was used to establish the plasma metabolic fingerprint. Multivariate statistical analysis was applied for comparing the differences of plasma metabolites between ZYP group and placebo group, 44 potential metabolites were screen out and identified. Pathway analysis was conducted with database mining. Compared with placebo, chemicals were found to be significantly down-regulated on HCG trigger day and 14 days after embryo transplantation, including trihexosylceramide (d18:1/26:1), glucosylceramide(d18:1/26:0), TG(22:6/15:0/22:6), TG(22:4/20:4/18:4). Compared with placebo, some chemicals were found to be significantly up-regulated on HCG trigger day and 14 days after embryo transplantation, i.e., PIP3(16:0/16:1), PIP2(18:1/18:1), tauroursodeoxycholic acid, L-asparagine, L-glutamic acid, kynurenic acid, 11-deoxycorticosterone, melatonin glucuronide, hydroxytyrosol. These metabolites were highly enriched in pathways including sphingolipid metabolism, alanine, aspartic acid and glutamic acid metabolism, aminoacyl tRNA biosynthesis, taurine and hypotaurine metabolism. This study revealed metabolic differences between subjects administered with ZYP and placebo. Relating metabolites were identified and pathways were enriched, providing basis on the exploration on the underlying mechanisms of ZYP combined with IVF-ET in the treatment of infertility.

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Section: Metabolism Of Alanine Aspartic Acid and Glutamic Acidmentioning

confidence: 99%

Metabonomics Study on the Infertility Treated With Zishen Yutai Pills Combined With In Vitro Fertilization-embryo Transfer

Ning²,

Wei

et al. 2021

Front. Pharmacol.

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“…According to other studies, glutamatergic and GABAergic transmission has been suggested to be affected by lithium's action [23]. Additionally, L-glutamic acid monosodium salt has been reported to attenuate Li-induced harmful influence on the development of animal embryos [18]. Research on the influence of lithium on different metabolic processes is all the more warranted because, apart from exposure resulting from medical application, the possibility of exposure to this element due to its presence in drinking water has been reported [28].…”

Section: Introductionmentioning

confidence: 97%

The influence of lithium and/or selenium on plasma amino acids profile in rats

Kiełczykowska¹,

Musik²,

Luchowska-Kocot³

et al. 2021

Ann Agric Environ Med.

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Introduction. Selenium belongs to essential microelements and is used in agriculture. Lithium is used in medicine and the possibility of its exposure by environmental pollution has been reported. Both elements have been found to be connected with amino acids metabolism. Objective. The aim of the study was to compare the effect of lithium and selenium on plasma amino acids in rats, and to evaluate the influence of selenium in organisms exposed to lithium. Materials and method. The effect of selenium (0.5 mg/kg b.w., orally as Na 2 SeO 3 ) and/or lithium (2.7 mg/kg b.w., orally as Li 2 CO 3 ) given for 6 weeks on the plasma profile of selected amino acids in rats was studied. The concentrations of amino acids were determined using ion exchange chromatography with the aid of an amino acids analyzer AAA400. Results. A significant effect of lithium on plasma amino acids profile was found in rats, much greater than for selenium. Selenium treatment slightly increased Tau, Phe, Tyr, Ala, Trp, Ser and Gln, while Lys and Orn were enhanced in a significant way. In contrast, Li-treatment caused a well-marked increase in Phe, Orn, Ala, His, Trp, Asp and Gln, whereas all the others were only slightly increased. Co-treatment resulted in a significant increase in Orn and Trp, a slight enhancement of Phe, Lys and His, while the rest remained unchanged. Conclusions. A significant effect of lithium alone on plasma amino acids profile in animals was demonstrated, with a much less influence of selenium alone. Co-treatment generally resulted in a slight or no effect. The slight selenium influence seems important regarding its agricultural application and the growing interest in its supplementation. Results concerning lithium could contribute to the research regarding the mechanism of Li action.

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Safety assessment of monosodium glutamate based on intestinal function and flora in mice

Tang

Liu

et al. 2022

Food Science and Human Wellness

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L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos

Cited by 4 publications

References 43 publications

Metabonomics Study on the Infertility Treated With Zishen Yutai Pills Combined With In Vitro Fertilization-embryo Transfer

Metabonomics Study on the Infertility Treated With Zishen Yutai Pills Combined With In Vitro Fertilization-embryo Transfer

The influence of lithium and/or selenium on plasma amino acids profile in rats

Safety assessment of monosodium glutamate based on intestinal function and flora in mice

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