L’extrait huileux au CO2 supercritique de baies et de graines d’argousier (Hippophae rhamnoides L.) et ses effets sur la peau et les muqueuses

Menvielle-Bourg, F. Joanny; Joanny, Fabienne

doi:10.1007/s10298-008-0358-3

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Some fixed vegetable oils extracted by various processes (solvent, supercritical CO 2 , and cold pressure) have been proven to heal skin wounds [48–52]. In a previous work, we showed the effectiveness of Opuntia ficus indica oil (OFI oil) extracted by cold pressing on the healing of full-thickness skin injury, as well as its antimicrobial effect against bacteria, yeast, and fungi [53].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Khémiri

Bitri

2019

Oxidative Medicine and Cellular Longevity

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Gastric ulcer is a painful lesion of the gastric mucosa which can be disabling, or even more very serious in the case of a perforation of the stomach and internal hemorrhage. Traditional pharmacopeias have shown the efficacy of various plant extracts in the treatment of this pathology. Some extracts from Opuntia ficus indica (OFI) have been proven to have medicinal therapeutic benefits. The aim of this study was to investigate the preventive and curative effects of OFI seed oil extracted by cold pressing on an ethanol-induced gastric ulcer model in rats. Gastroprotective activities of the oil were assessed as pretreatments prior to ethanol gavage of Wistar rats compared to reference drugs. Two oil dose effects were tested. Ulcer and gastric parameters were measured (ulcerated areas (mm2), % of ulcer inhibition, gastric juice volume and pH, and mucus weight). Macroscopical and microscopical assessments of the stomachs as well as gastric biopsy histological studies were carried out. OFI oil exhibited a high efficiency in the protection of the cytoarchitecture and function of the gastric mucosa against the severe damages provoked by ethanol intake. Ulcerated areas were very significantly reduced and the % of ulcer inhibition was the highest under OFI oil pretreatment. Mucus production was stimulated, gastric juice volume was reduced, and its pH was increased. Histopathological examination of H&E-stained biopsies collected from gastric mucosae from the different experimental groups confirmed the gastroprotective efficacy of OFI oil against ethanol-induced symptoms such as inflammation and damages like bleeding, erosions, lesions, necrosis, and ulcers. Furthermore, OFI oil treatment speeded-up the reduction of the surface of ethanol-induced ulcerated areas in a dose-dependent manner, leading to a time gain in the healing process. The healing rate reached 91% on day 2 and 99% on day 3, and a complete heal was attained at the fourth day under OFI oil treatment, while ulcer areas were still partially unhealed in all the other groups. The therapeutic effects of OFI oil against gastric ulcer could be mediated by its varied bioactive compounds that we have demonstrated in the analytical study. They could act synergistically or in a delayed manner to optimize the healing process through protective antioxidant properties, as well as an antagonism against histamine H2-receptors, a stimulation of the signaling pathways necessary for mucus and bicarbonate production, and reduction of inflammatory processes in the gastric mucosa. Additionally, OFI oil fatty acids (especially unsaturated) and triacylglycerols contribute to the reconstruction and the repair of the cell membrane lipid bilayer during the gastric ulcer healing process.

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Section: Introductionmentioning

confidence: 99%

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Khémiri

Bitri

2019

Oxidative Medicine and Cellular Longevity

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“…It was reported that by the end of ripening, the enzymatic activity of phytosterol biosynthesis stops in fruits. During this period, the phytosterols are no longer synthesized but are converted into other compounds [44]. The total phytosterol content was 128.56 ± 2.40 mg/100 g in the HEAI, reflecting a high concentration of dietary phytosterols that could efficiently reduce the cholesterol level in the blood [25,42].…”

Section: Chromatographic Characterization Of Phytosterols By Gc-msmentioning

confidence: 99%

Section: Chromatographic Characterization Of Phytosterols By Gc-msmentioning

confidence: 99%

Physicochemical Analysis and Wound Healing Activity of Azadirachta indica (A. Juss) Fruits

Boukeloua

Kouadria

Bendıf³

et al. 2023

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(1) Background: The neem tree, Azadirachta indica (A. Juss), is a well-known species used in traditional medicine for the treatment of skin conditions such as irritation, eczema, burns, and wounds. The objective of the current study was to investigate the physicochemical and wound-healing properties of A. indica fruits. (2) Methods: Gas chromatography coupled with mass spectrometry (GC-MS) was used to determine the content of fatty acids and phytosterols, and high-performance liquid chromatography (HPLC) was used to determine the tocopherol content. The wound-healing activity was observed on the backs of six adult male rabbits. (3) Results: The results showed that the plant contained fatty acids, as well as oleic (46.05%), palmitic (23.94%), linoleic (11.39%), and stearic (7.87%) acids. The phytosterols were three major compounds; in decreasing order of importance, they were β-sitosterol (97.26 mg/100 g), campesterol (18.94 mg/100 g), and stigmasterol (12.05 mg/100 g). There were also traces of cholesterol. The neem was a moderate source of vitamin E (α-tocopherol, 14.86 mg/100 g). The hexane extracts showed no acute toxicity and low eye and skin irritability and had reasonable safety and important wound-healing activity. (4) Conclusions: The results confirmed that A. indica is a valuable source of fatty acids, phytosterols, and vitamin E and is efficient in the process of wound healing.

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L’extrait huileux au CO2 supercritique de baies et de graines d’argousier (Hippophae rhamnoides L.) et ses effets sur la peau et les muqueuses

Cited by 2 publications

References 6 publications

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Physicochemical Analysis and Wound Healing Activity of Azadirachta indica (A. Juss) Fruits

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