L’évaluation prospective de la fonction cardiaque chez les patientes traitées pour cancer du sein par anthtracyclines en adjuvant: résultats préliminaires

Mesbahi, Omar El; Mrabet, F.Z.; Ouaha, L.; Lahlou, I.; Najid, I.; Akoudad, H.

doi:10.1007/s12558-011-0190-9

Cited by 1 publication

(1 citation statement)

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“…Multivariate analysis pointed out that BMI was relevant to ACT (10). Similarly, some studies have found that higher BMI was related to ACT in the treatment of BC (32)(33)(34)(35). It can clearly be seen that this study did not get consistent results with the above.…”

Section: Discussioncontrasting

confidence: 58%

Risk Factors for Anthracycline-Induced Cardiotoxicity in Breast Cancer Treatment: A Meta-Analysis

Zhang

Yang

et al. 2022

Front. Oncol.

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BackgroundAnthracyclines play an important role in the treatment of breast cancer (BC) and other malignant tumors. However, accompanied side-effects are non-ignorable. The purpose of this meta-analysis is to determine the risk factors for anthracycline-induced cardiotoxicity (ACT), so as to identify high-risk patients.MethodsThe search for literature was conducted in PubMed, The Cochrane Library, Embase and Web of science. Records were selected with inclusion criteria and exclusion criteria. The newcastle-ottawa scale (NOS) was used to assess the quality of literature, and Review Manager 5.3 software was used for meta-analysis.ResultsThirteen studies met the inclusion criteria. Meta-analysis indicated that risk factors for ACT were use of trastuzumab (odds ratio [OR]: 2.84, 95% confidence interval [CI]: 2.49-3.22, p < 0.00001), cumulative dose of anthracyclines (OR: 1.45, 95%CI: 1.28-1.65, p < 0.00001), hypertension (OR: 2.95, 95%CI: 1.75-4.97, p < 0.0001), diabetes mellitus (DM) (OR: 1.39, 95%CI: 1.20-1.61, p < 0.0001), tumor metastasis (OR: 1.91, 95%CI: 1.17-3.11, p = 0.009) and coronary heart disease (CAD) (OR: 2.17, 95%CI: 1.50-3.15, p < 0.0001). In addition, our analysis revealed that body mass index (BMI) had no effect on ACT (OR: 1.18, 95%CI: 0.98-1.43, p = 0.08).ConclusionsPatients with high risk for ACT can be identified by these factors. For such patients, a higher level of monitoring and protection for the cardiac function should be performed by clinicians.Systematic Review RegistrationINPLASY, identifier INPLASY202250140.

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