L'épidémiologie de diphtérie en Algérie (1993–1995). Données bactériologiques

Belhocine, S.; Rahal, K

doi:10.1016/s0399-077x(97)80057-1

Cited by 4 publications

(2 citation statements)

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“…In the past, until 1990, sporadic reported diphtheria cases were represented mainly by the 2-to 6-years-old group [33]. This shift to the older age groups was previously reported in outbreaks occurring in Algeria in 1993e1995 by Belhocine et al [33]. These data correlate with epidemics in the 1990s in the former Soviet Union [34].…”

Section: Diphtheriamentioning

confidence: 65%

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Microbiological and molecular characterization of Corynebacterium diphtheriae isolated in Algeria between 1992 and 2015

Benamrouche

Hasnaoui

Badell

et al. 2016

Clinical Microbiology and Infection

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The objectives of this study were to undertake the microbiological and molecular characterization of Corynebacterium diphtheriae isolates collected in Algeria during epidemic and post-epidemic periods between 1992 and 2015. Microbiological characterization includes the determination of biotype and toxigenicity status using phenotypic and genotypic methods. Antimicrobial susceptibility was determined by the E-test method. Molecular characterization was performed by multi-locus sequence typing. In total, there were 157 cases of C. diphtheriae isolates, 127 in patients with respiratory diphtheria and 30 with ozena. Isolates with a mitis biotype were predominant (122 out of 157; 77.7%) followed by belfanti (28 out of 157; 17.8%) and gravis biotype (seven out of 157; 4.5%). Toxigenic isolates were predominant in the period 1992-2006 (74 out of 134) whereas in the period 2007-2015, only non-toxigenic isolates circulated (23 out of 23). All 157 isolates were susceptible to erythromycin, gentamicin, vancomycin and cotrimoxazole. Reduced susceptibility to penicillin G, cefotaxime, tetracycline and chloramphenicol was detected in 90 (57.3%), 88 (56.1%), 112 (71.3%) and 90 (57.3%) isolates, respectively. Multi-locus sequence typing analysis indicates that sequence type 116 (ST-116) was the most frequent, with 65 out of 100 isolates analysed, in particular during the epidemic period 1992-1999 (57 out of 65 isolates). In the post-epidemic period, 2000-2015, 13 different sequence types were isolated. All belfanti isolates (ten out of 100 isolates) belonged to closely related sequence types grouped in a phylogenetically distinct eBurst group and were collected exclusively in ozena cases. In conclusion, the epidemic period was associated with ST-116 while the post-epidemic period was characterized by more diversity. Belfanti isolates are grouped in a phylogenetically distinct clonal complex.

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Section: Diphtheriamentioning

confidence: 65%

“…In our study, patients with diphtheria were mainly belonged to the 11-to 20-years-old group. In the past, until 1990, sporadic reported diphtheria cases were represented mainly by the 2-to 6-years-old group [33]. This shift to the older age groups was previously reported in outbreaks occurring in Algeria in 1993e1995 by Belhocine et al [33].…”

Section: Diphtheriamentioning

confidence: 67%