L'éosinopénie : un critère discriminant en faveur des infections microbiennes au cours des syndromes inflammatoires inexpliqués, à propos de 106 cas

Gil, H.; Magy, N.; Mauny, Frédéric; Navellou, C.; Dupond, A.S.; Arnaudo, J.P.; Dupond, J.L.

doi:10.1016/s0248-8663(00)90084-5

Cited by 5 publications

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“…Eosinopenia has been identi ed as a sign of acute infection for a long time [6][7][8] and its correlation with sepsis was rstly reported by Abidi et.al in 2008 [22].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, seeking timely, sensitive and speci c biomarkers has become the research focus in this eld, with C reaction protein (CRP), procalcitonin (PCT) and white blood cell count as potential candidates, while the e ciency is far below satisfaction [3,4] Eosinophils, comprising 1%-3% of circulating leukocytes, play a role in host defense against helminths and the propagation of allergic conditions, and are considered as an integral part of immune and in ammatory network, and homeostatic regulation as well in recent years [5]. The reduction of circulating eosinophil count (namely eosinopenia) in response to acute infection was rstly described in 1893 by Zappert et al [6], and is now acknowledged as a signal of acute infection [7,8]. The feasibility of eosinopenia in diagnosis of sepsis was rstly tested by Abidi et al, who showed that eosinopenia is good at discriminating between non-infection and infection, but is rather weak in differentiating sepsis from systemic in ammatory response syndrome (SIRS) [9].…”

Section: Introductionmentioning

confidence: 99%

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Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Lin¹,

Rong²,

Zhang³

2020

Preprint

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BackgroundSepsis is a life-threatening and time-critical medical emergency, therefore, the early diagnosis of sepsis is essential to timely treatment and favorable outcomes for patients susceptible to sepsis. Eosinopenia has been identified as a potential biomarker of sepsis in the past decade. So, we performed a meta-analysis to assess the diagnostic efficacy of eosinopenia for sepsis.MethodWe searched PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials CENTRAL databases to identify studies that met the inclusion criteria. Two authors performed data extraction independently. The pooled outcomes were calculated by TP (true positive), FP (false positive), FN (false negative), TN (true negative) by using bivariate meta-analysis model in STATA 14.0 software. ResultsSeven studies were included in the present study with a total number of 3842 subjects. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 0.66 (95%CI [0.53-0.77]), 0.68 (95%CI [0.56-0.79]), 2.09 (95%CI [1.44-3.02]), 0.49 (95%CI [0.34-0.71]) and 4.23 (95%CI [2.15-8.31]), respectively. The area under the summary receiver operator characteristic curve (SROC) was 0.73 (95%CI [0.68-0.76]). Meta-regression analysis revealed that no single parameter accounted for the heterogeneity of pooled outcomes. For each subgroup of different eosinopenia cutoff values (50, 40, <=25, 100), the sensitivity was 0.61, 0.79, 0.57, 0.54, and the specificity was 0.61, 0.75, 0.83, 0.51, respectively. ConclusionsOur findings suggest that eosinopenia shows no superiority in the diagnosis of sepsis. Further large clinical trials are needed to re-evaluate eosinopenia as a biomarker of sepsis.

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“…Eosinopenia has been identi ed as a sign of acute infection for a long time [6][7][8] and its correlation with sepsis was rstly reported by Abidi et.al in 2008 [22].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Lin¹,

Rong²,

Zhang³

2020

Preprint

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“…It was first described by Zappert in 1893 (19) and in the early 1900s, was considered a useful diagnostic tool (20). Gil and colleagues observed that sepsis associated with an eosinophil count <40 cells/mm 3 is related to bacterial infections (21). In acute bacterial infection of infants, absolute eosinophil count of zero was reported (22,23).…”

Section: Discussionmentioning

confidence: 99%

Role of absolute eosinopenia as marker of enteric fever: Experience from a Tertiary Care Hospital in the United Arab Emirates

Lokhandwala

Athar

Turrin³

2012

Ibnosina Journal of Medicine and Biomedical Sciences

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Background: Involvement of bone marrow is common in salmonella infections. Enteric fever is a cause of morbidity and mortality world wide. Materials and Methods: We conducted a retrospective study of 51 blood cultures or widal positive salmonella patients who were admitted to a tertiary care hospital. Medical records and laboratory information system were used to collect the data. Results: The result established that significant eosinopenia was present in all enteric fever patients and eosinophil count of zero was almost diagnostic of enteric fever in the right clinical setting. Conclusion: Absolute eosinopenia is an important finding that should help timely diagnosis and early treatment initiation of enteric fever.

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“…However, literature between eosinophils and infectious diseases -helminthes apart -appears to be scarce. One study found that eosinophil count under 40/mm3 with elevated white cell count (over 10,000/mm3) was associated with bacterial infectious diseases (14,15). Another study found that eosinophils < 10/mm 3 alone or in association with elevated white blood cell count or high CRP blood level was strongly associated with sepsis (speci city 94-98 %) in an emergency department (16).…”

Section: Introductionmentioning

confidence: 99%

Association between low eosinophil count and mortality in SARS-COV-2 infection on the 70+, a discussed observation

Baudouin¹,

Kosowki²,

Mesinele³

et al. 2021

Preprint

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Background: Biological COVID-19 abnormalities are varied (lymphopenia, high levels of blood inflammatory markers, …). Regarding physiological immune responses, eosinophils were for a long time thought to be mainly against extra-cellular pathogen like helminthes. It has recently been pointed out that they appear to play a part in recognition of virus and to have the capacity to perform direct action against viruses. This study aimed to seek for an association between eosinophils count < 10 /mm3 and mortality in an older adults suffering from COVID-19 hospitalized in a specific geriatric ward. Methods: This observational retrospective study was conducted in a French geriatric ward from March 17 to April 18, 2020. All 118 patients hospitalized for COVID-19 over 70 yo in acute stay care were enrolled. Patients with a treatment or a condition which could interfere with eosinophil count were excluded. Results: No statistical difference was found between surviving or deceased patient regarding age (mean age (SD): 87 years (7)) and sex (34% of males). Differences for the most frequent acute events were statically different: Quick Sepsis-related Organ Failure Assessment (qSOFA) score was ≥ 2 at admission for 23% in the survivor group vs 72% in the deceased (p < .001); acute kidney injury concerned 17% of the survivors vs. 69% of the decease (p< .001). Eosinophil count < 10/mm3 was significantly associated with mortality (OR (95% CI)) = 3.54 (1.23-11.4) after adjustment on age, gender, and activity of daily living.Conclusion: Low eosinophil count (< 10/mm3) seems to be associated with mortality on older adults. Due to the specific physiological ageing process of the immune system, this calls to explore more globally the impact of inflammaging and immunosenescence on SARS-CoV-2 infection in this population.

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L'éosinopénie : un critère discriminant en faveur des infections microbiennes au cours des syndromes inflammatoires inexpliqués, à propos de 106 cas

Cited by 5 publications

References 0 publications

Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Role of absolute eosinopenia as marker of enteric fever: Experience from a Tertiary Care Hospital in the United Arab Emirates

Association between low eosinophil count and mortality in SARS-COV-2 infection on the 70+, a discussed observation

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L'éosinopénie : un critère discriminant en faveur des infections microbiennes au cours des syndromes inflammatoires inexpliqués, à propos de 106 cas

Cited by 5 publications

References 0 publications

­Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

­Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Role of absolute eosinopenia as marker of enteric fever: Experience from a Tertiary Care Hospital in the United Arab Emirates

Association between low eosinophil count and mortality in SARS-COV-2 infection on the 70+, a discussed observation

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Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis

Revisit Eosinopenia as a Biomarker for Diagnosis of Sepsis: A Meta-Analysis