L’éosinopénie en 2018

Gil, H.; Bouldoires, B.; Bailly, B.; Ruault, Nadine Meaux; Humbert, S.; Magy-Bertrand, Nadine

doi:10.1016/j.revmed.2018.11.008

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…Low eosinophil counts is often related to the use of glucosteroids [39]. Eosinopenia is also considered as a surrogate of inflammation in bacterial infections [40] or myocardial infarction [41]. Basophil counts could be reduced by chronic urticaria or with steroids [42].…”

Section: Plos Onementioning

confidence: 99%

Pre-test probability for SARS-Cov-2-related infection score: The PARIS score

et al. 2020

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Introduction In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans. This study aimed to determine a pre-test probability score for SARS-CoV-2 infection. Methods This multicenter retrospective study (4 University Hospitals) included patients with clinical suspicion of SARS-CoV-2 infection. Demographic characteristics, clinical symptoms, and results of blood tests (complete white blood cell count, serum electrolytes and CRP) were collected. A pre-test probability score was derived from univariate analyses of clinical and biological variables between patients and controls, followed by multivariate binary logistic analysis to determine the independent variables associated with SARS-CoV-2 infection. Results 605 patients were included between March 10th and April 30th, 2020 (200 patients for the training cohort, 405 consecutive patients for the validation cohort). In the multivariate analysis, lymphocyte (<1.3 G/L), eosinophil (<0.06 G/L), basophil (<0.04 G/L) and neutrophil counts (<5 G/L) were associated with high probability of SARS-CoV-2 infection but no clinical variable was statistically significant. The score had a good performance in the validation cohort (AUC = 0.918 (CI: [0.891–0.946]; STD = 0.014) with a Positive Predictive Value of high-probability score of 93% (95%CI: [0.89–0.96]). Furthermore, a low-probability score excluded SARS-CoV-2 infection with a Negative Predictive Value of 98% (95%CI: [0.93–0.99]). The performance of the score was stable even during the last period of the study (15-30th April) with more controls than infected patients. Conclusions The PARIS score has a good performance to categorize the pre-test probability of SARS-CoV-2 infection based on complete white blood cell count. It could help clinicians adapt testing and for rapid triage of patients before test results.

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Section: Plos Onementioning

confidence: 99%

Pre-test probability for SARS-Cov-2-related infection score: The PARIS score

et al. 2020

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“…Eosinophils are circulating and tissue-resident leukocytes, which show proinflammatory, immunoregulatory and antiviral effects [15]. Eosinopenia has been reported in different medical conditions such as bacterial infections, acute inflammation, stress or corticosteroid therapy [16][17][18]. In the setting of COVID-19, eosinopenia may be related to the migration of these cells into the peripheral tissues or to a decreased production of eosinophils into the bone marrow, due to the inflammatory state [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Eosinopenia in COVID-19 Patients: A Retrospective Analysis

et al. 2020

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Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm3. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic—ROC curve, 0.84 (95% CIs 0.78–0.90) and 0.84 (95% CIs 0.77–0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available.

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“…ist teuer, zeitaufwendig und häufig ungenau [1], was das Gesundheitssystem zunehmend finanziell belastet. Die Bestimmung von Eosinophilen und der Nachweis und die Persistenz der Eosinopenie (Mangel von Eosinophilen) deuten einen komplizierten Verlauf [2] der COVID-19-Infektion an [3]. Weitere Studien über die Funktion der Eosinophilen während der COVID-19-Infektion sind erforderlich.…”

Section: Transfer In Die Praxis Von Dr Dr Panagiota Xanthouli (Heidelberg)unclassified

Eosinopenie als Biomarker des Schweregrads einer COVID-19-Infektion

Xanthouli

2021

Kompass Pneumol

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Background: Studies on the role of eosinophils in coronavirus disease 2019 (COVID-19) are scarce, though available findings suggest a possible association with disease severity. Our study analyzes the relationship between eosinophils and COVID-19, with a focus on disease severity and patients with underlying chronic respiratory diseases. Methods: We performed a retrospective analysis of 3018 subjects attended at two public hospitals in Madrid (Spain) with PCR-confirmed SARS-CoV-2 infection from January 31 to April 17, 2020. Patients with eosinophil counts less than 0.02×109/L were considered to have eosinopenia. Individuals with chronic respiratory diseases (n = 384) were classified according to their particular underlying condition, i.e., asthma, chronic pulmonary obstructive disease, or obstructive sleep apnea. Results: Of the 3018 patients enrolled, 479 were excluded because of lack of information at the time of admission. Of 2539 subjects assessed, 1396 patients presented an eosinophil count performed on admission, revealing eosinopenia in 376 cases (26.93%). Eosinopenia on admission was associated with a higher risk of intensive care unit (ICU) or respiratory intensive care unit (RICU) admission (OR:2.21; 95%CI:1.42–3.45; p <0.001) but no increased risk of mortality (p >0.05). Conclusion: Eosinopenia on admission conferred a higher risk of severe disease (requiring ICU/RICU care), but was not associated with increased mortality. In patients with chronic respiratory diseases who develop COVID-19, age seems to be the main risk factor for progression to severe disease or death.

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L’éosinopénie en 2018

Cited by 7 publications

References 39 publications

Pre-test probability for SARS-Cov-2-related infection score: The PARIS score

Pre-test probability for SARS-Cov-2-related infection score: The PARIS score

Eosinopenia in COVID-19 Patients: A Retrospective Analysis

Eosinopenie als Biomarker des Schweregrads einer COVID-19-Infektion

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