L’entraînement des muscles inspiratoires en réhabilitation respiratoire

Beaumont, Marc; Tallec, F. Le; Villiot-Danger, Estelle

doi:10.1016/j.rmr.2021.04.003

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…In recent years, studies have shown that patients with different degrees of COPD can benefit from pulmonary Rehabilitation and exercise Training, including improved activity tolerance, reduced dyspnea and improved quality of life [ 33 , 34 ]. For the majority of COPD patients, IMT is an effective stand-alone intervention that can be transitioned to aerobic and resistance training as part of a multidimensional respiratory rehabilitation training program for patients with dyspnea and exercise intolerance, as well as for patients who avoid activity due to fear of motor dyspnea [ 35 ]. Studies have shown that IMT therapy can increase type I and type II fibers of intercostal external muscles, induce remodeling of training muscles, and change the adaptive structure of respiratory muscles [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway

Lei,

He,

et al. 2023

BMC Pulm Med

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Background Pulmonary rehabilitation training is of great significance for the prognosis of chronic obstructive pulmonary disease (COPD) patients. The purpose of this study was to investigate the therapeutic effect and pathway of a new sequential noninvasive positive pressure ventilation (NIPPV) + inspiratory muscle training (IMT) therapy. Methods A total of 100 COPD patients were enrolled and randomly divided into oxygen therapy (OT), NIPPV, IMT and sequential (NIPPV + IMT) group. Lung function, exercise endurance, quality of life, and dyspnea symptoms were examined and recorded. Then, reactive oxygen species (ROS), malonaldehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) levels were detected by enzyme-linked immunoassay, and suppressor of cytokine signaling 5 (SOCS5)/janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway expression changes were detected by quantitative real time-polymerase chain reaction (qRT-PCR) and western blot. A mouse model of COPD was then established to further verify the effects of SOCS5/JAK2/STAT3 pathways on lung function and oxidative stress. Results After 8 weeks of treatment, NIPPV, IMT or sequential (NIPPV + IMT) significantly improved exercise endurance, quality of life and dyspnea, reduced oxidative stress, promoted SOCS5 expression and inhibited the activation of JAK2/STAT3 pathway, and no significant effect was observed on lung function of COPD patients. Notably, sequential (NIPPV + IMT) showed better therapeutic outcomes than either IMT or NIPPV alone. Moreover, results at the animal level showed that overexpression of SOCS5 significantly reduced pulmonary inflammatory infiltration, pathological changes and oxidative stress levels in COPD mice, enhanced lung function, and inhibited the activation of JAK2/STAT3 pathway. Conclusion Our results elucidated that sequential (NIPPV + IMT) significantly relieved COPD development by regulating SOCS5/JAK2/STAT3 signaling-mediated oxidative stress.

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