L’encéphalite à anticorps antirécepteur au NMDA : une cause sous estimée de psychose aiguë chez l’enfant et l’adulte jeune

Beaudonnet, Frédérique; Garrec, Nathalie; Sfez, A.; Epain, Véronique; Secret, Isabelle; Angenard, F; Wafo, Estelle; Deiva, Kumaran; Chalvon-Demersay, A

doi:10.1016/j.lpm.2011.07.014

Cited by 2 publications

(1 citation statement)

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“…The most frequent are encephalitis with anti-NMDAr (N-methyl-D-aspartate receptors) and anti-VGKC (Voltage-Gated Potassium Channel) antibodies, the antigenic targets of which are the CASPR2 (Contact in-associated protein-like 2) and LGI1 (Leucine-rich Glioma-Inactivated 1) [18,23]. Their clinical presentation is better individualized and often stereotyped [7,14,22,26]. The clinical manifestations are heterogeneous and depend on the type of antibody involved, even though the most common clinical presentation is an acute or subacute limbic encephalitis, which manifests with neuropsychiatric symptoms, and sometimes extra limbic manifestations, such as signs of dysautonomia, abnormal movements, dyskinesias, and ataxia [4,16].…”

Section: Introductionmentioning

confidence: 99%

Dysimmune Encephalitis: Clinical Study

Hakim¹,

Daoudi²

2023

JNNR

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Introduction: Autoimmune encephalitis is a new and little-known entity targeting CNS antigens. It often causes inflammatory limbic encephalitis, for which immunotherapy is effective. Objective: The main objective of the study is to determine the clinical and paraclinical characteristics of encephalitides associated with NMDAr, CASPR2 and LGI1 antibodies. Materials and methods: It are a descriptive, prospective and retrospective study, which started from January 2016 to December 2018. Results: Our cohort included 30 patients with a mean age of 44±18.05 years. The limbic encephalitis was acute in 73.3%. The patients presented mainly psychiatric and vigilance disorders, epileptic seizures, dysautonomia, and memory disorders. A temporal hyper signal (± extra limbic) was often found on MRI, with non-specific abnormalities in the EEG and an inflammatory CSF profile. FBDS, dyskinesias, and neuro myotonia were the discriminating signs. Neoplasia was found in 16.7% of the cases. Immunotherapy led to good results. Conclusion: This study aimed to know how to identify these entities in our country and establish an early and effective treatment for better outcomes. A study with large samples would be more beneficial.

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