l-Cysteine capped Mn-doped ZnS quantum dots as a room temperature phosphorescence sensor for in-vitro binding assay of idarubicin and DNA

Ertaş, Nusret; Kara, Hayriye Eda Şatana

doi:10.1016/j.bios.2015.03.055

Cited by 35 publications

(16 citation statements)

References 24 publications

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“…The phosphorescent spectrum shows a prominent orange emission band at $ 598 nm, which is associated to the internal Mn 2 þ ion transition between the 4 T 1 first excited state (spin 3/2) and the 6 A 1 ground state (spin 5/2) (Beltran-Huarac et al, 2013). Note that the blue band at $416 nm (ascribed to the nanostructure surface states) typically observed in dual-emitting ZnS:Mn QDs was not detected by the spectrometer since it was operated in phosphorescence mode (Ertas et al, 2015) The blue band of the QDs when the spectrometer is operated in fluorescence mode was reported in our previous work (Diaz-Diestra et al, 2015). The internal transition is assumed to cause energy transfer from s-p electronhole pair band states (host ZnS nanocrystal) to the Mn 2 þ ion delectron states.…”

Section: Characterization Of L-cysteine Capped Zns:mn Quantum Dotsmentioning

confidence: 94%

“…Its optical sensing is based on the interaction of a fraction of atoms/molecules on a treated surface, which strongly affects the recombination of electrons and holes within the particles, and in turn the emission response . Following this process, many analytes have been successfully detected, such as ions (Hg 2 þ , Co 2 þ , Zn 2 þ and Zr 4 þ ) (Bian et al, 2014;Gong et al, 2014a;Ren et al, 2011;Tan et al, 2012); proteins/enzymes, clenbuterol and glucose in biological fluids (Gong et al, 2014b;Wu et al, 2013;Wu et al, 2010;Zhang et al, 2013); organophosphorus pesticides (Ban et al, 2014); phenols in different media (Liu et al, 2010;Wei et al, 2015;Zhang et al, 2015b); and cathecol, domoic acid, rutin, urea, idarubicin and DNA (Bi et al, 2014;Dan et al, 2013;Ertas et al, 2015;Miao et al, 2014;Wang et al, 2013). Recently, Bian and co-workers, employing N-acetyl-L-cysteine and L-cysteine capped ZnS:Mn QDs as probes, showed the luminescent detection of L-ascorbic acid (AA) with high selectivity and long luminescence lifetime (Bian et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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L-cysteine capped ZnS:Mn quantum dots for room-temperature detection of dopamine with high sensitivity and selectivity

Diaz-Diestra

Thapa

Beltran‐Huarac

et al. 2017

Biosensors and Bioelectronics

117

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Dopamine (DA) is one of the most important catecholamine neurotransmitters of the human central nervous system, and is involved in many behavioral responses and brain functions. Below normal DA levels in biological fluids can lead to different neurodegenerative conditions. For excess DA levels, a failure in energy metabolism is indicated. In this study, a facile room-temperature phosphorescence sensor is developed to detect DA based on l-cysteine capped Mn doped ZnS quantum dots (l-cys ZnS:Mn QDs). The QDs display a prominent orange emission band peaking at ~598nm, which is strongly quenched upon addition of DA in alkaline medium. The sensor exhibits a linear working range of ~0.15-3.00μM, and a limit of detection of ~7.80nM. These results are explained in terms of a pH-dependent electron transfer process, in which the oxidized dopamine quinone functions as an efficient electron acceptor. The QDs-based sensor shows a high selectivity to DA over common interfering biomolecules (including some amino acids, ascorbic acid, chloride and glucose). The sensor has been successfully applied for the detection of DA in urine samples, yielding recoveries as high as 93%. Our findings indicate that our developed sensor exhibits high sensitivity and reproducibility to determine DA even in biological fluids where DA is at low levels, e.g., in the central nervous system, which is the usual clinical profile of a neurodegenerative disorder associated to the Parkinson's disease.

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Section: Characterization Of L-cysteine Capped Zns:mn Quantum Dotsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

L-cysteine capped ZnS:Mn quantum dots for room-temperature detection of dopamine with high sensitivity and selectivity

Diaz-Diestra

Thapa

Beltran‐Huarac

et al. 2017

Biosensors and Bioelectronics

117

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“…35 Briefly, 50 mL of 0.02 M L-cysteine, 5 mL of 0.1 M ZnSO 4 , and 1.5 mL of 0.01 M MnCl 2 were added to a flask and mixed. Then the pH of the mixture was adjusted to 11 with 1 M NaOH.…”

Section: Synthesis Of the Mn-doped Zns Qdsmentioning

confidence: 99%

“…35 The QDs showed a broad UV absorption band between 200 nm and 300 nm with two maxima at around 209 and 290 nm ( Figure 1a). The phosphorescence spectrum of L-cysteine-capped Mn-doped ZnS QDs exhibited a maximum phosphorescence emission peak at 590 nm when excited at 290 nm.…”

Section: Characterization Of the Mn-doped Zns Qdsmentioning

confidence: 99%

“…35 This orange emission band was based on the incorporation of Mn 2+ ions on the Zn 2+ sites and transition from the triplet state to the ground state in the ZnS host lattice. 36 The photoluminescence quantum yield (PL-QY) of QDs was determined using a fluorescent dye, namely quinine, as a reference standard and was found as 20.3%.…”

Section: Characterization Of the Mn-doped Zns Qdsmentioning

confidence: 99%

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Mn-doped ZnS quantum dots as a room-temperature phosphorescent probe for analysis of glutamic acid in foodstuffs

Kara¹,

Demirhan²,

Demirhan³

2016

Turk J Chem

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L-cysteine-capped Mn-doped ZnS quantum dots (QDs) were used for the determination of glutamic acid in foodstuffs. This method is based on measurement of the quenching of the phosphorescence intensity of the QDs after interacting with glutamic acid. A linear response was observed from 50 to 500 ng mL −1 glutamic acid with a limit of detection of 6.79 ng mL −1 . Room temperature phosphorescence (RTP) intensity of the QDs was quenched rapidly upon the addition of the quencher and the reaction reached equilibrium within 2 min. The quenching mechanism of phosphorescence of Mn-doped ZnS QDs by glutamic acid is dynamic and the quenching constant was found as 1.9× 10 5 M −1 . The developed method has some advantages such as freeness of interference from autofluorescence or common cations. The results showed that the proposed method is sensitive, selective, and fast, and does not require a derivatization step.

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Ultrasensitive Phosphorescence Sensors

Lu,

Jahanzamin,

Yan

et al. 2023

Organic and Inorganic Materials Based Sensors

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l-Cysteine capped Mn-doped ZnS quantum dots as a room temperature phosphorescence sensor for in-vitro binding assay of idarubicin and DNA

Cited by 35 publications

References 24 publications

L-cysteine capped ZnS:Mn quantum dots for room-temperature detection of dopamine with high sensitivity and selectivity

L-cysteine capped ZnS:Mn quantum dots for room-temperature detection of dopamine with high sensitivity and selectivity

Mn-doped ZnS quantum dots as a room-temperature phosphorescent probe for analysis of glutamic acid in foodstuffs

Ultrasensitive Phosphorescence Sensors

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