L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis

Nakanishi, Hiroyuki; Kurosaki, Masayuki; Tsuchiya, Kaoru; Nakakuki, Natsuko; Takada, Hitomi; Matsuda, Shuya; Gondo, Kouichi; Asano, Yoshihiro; Hattori, Nobuhiro; Tamaki, Nobuharu; Suzuki, Shinichi; Yasui, Yutaka; Hosokawa, Takanori; Itakura, Jun; Takahashi, Yuka; Izumi, Namiki

doi:10.1016/j.cgh.2014.12.005

Cited by 62 publications

(61 citation statements)

References 11 publications

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“…L-carnitine has also been shown to alleviate muscle weakness and aches, and decrease the visual analog pain scale score in patients with cirrhosis [2]. Carnitine is associated with the import of long-chain fatty acids into mitochondria for β-oxidation, which is the major source of energy for cardiac and skeletal muscle cells [11].…”

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confidence: 99%

Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps

et al. 2018

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Abstract. Diabetic patients often suffer from muscle cramps. This study aimed to compare the quality of life (QOL) of diabetic patients with and without muscle cramps and to investigate the effect of L-carnitine supplementation in diabetic patients with muscle cramps. A total of 91 patients with diabetes were enrolled in this study: 69 patients with muscle cramps and 22 patients without muscle cramps. Muscle cramps and QOL were evaluated using the muscle cramp questionnaire and the Short Form 36 health survey version 2 (SF-36), respectively. Clinical characteristics were compared between diabetic patients with and without muscle cramps. In the prospective portion of the study, 25 diabetic patients with muscle cramps received L-carnitine supplementation (600 mg/day orally) for 4 months. The questionnaires were administered before and after supplementation. The SF-36 scores in diabetic patients with muscle cramps were lower than those in patients without muscle cramps on the subscales of physical function, role physical, bodily pain, vitality, general health, and social function. In the 25 patients with muscle cramps who received L-carnitine supplementation, the monthly frequency of muscle cramps and WongBaker FACES ® Pain Rating Scale scores were significantly decreased. Scores on the following SF-36 subscales improved after L-carnitine supplementation: body pain, vitality, social function, and role emotional. This study demonstrated that muscle cramps decrease the QOL in patients with diabetes, and L-carnitine supplementation may improve the QOL by reducing the frequency and severity of muscle cramps in these patients.

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Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps

et al. 2018

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“…A dose of 2 g or more is commonly used in studies outside of Japan. In contrast, a Japanese study on carnitine dosage demonstrated that both 900 and 1200 mg were effective in reducing muscle cramps, with the higher dose showing a greater effect [22]. Therefore, we used a new formulation, a 1000 mg FF tablet, which is equivalent to the 1200 mg dose used in the above report.…”

Section: Discussionmentioning

confidence: 99%

L-carnitine reduces ammonia levels and alleviates covert encephalopathy: A randomized trial

Nojiri¹,

Fujiwara²,

Matsuura³

et al. 2018

J Transl Sci

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“…In the field of clinical practice, Malaguarnera reported that LC patients treated with L-carnitine showed greater reductions in serum ammonia levels as well as improvements in neuropsychological functioning in comparison with placebo [13]. On the other hand, Nakanishi et al demonstrated in their prospective study that L-carnitine reduces muscle cramps in LC patients [14]. …”

Section: Introductionmentioning

confidence: 99%

Effect of L-Carnitine in Patients With Liver Cirrhosis on Energy Metabolism Using Indirect Calorimetry: A Pilot Study

et al. 2016

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Background: L-carnitine supplementation has been suggested to show several favorable effects on patients with liver cirrhosis (LC). However, there have been no reports regarding the effect of L-carnitine on energy metabolism in patients with LC using indirect calorimetry which is a well-established method for assessing the degree of liver malnutrition. We examined the effect of L-carnitine in patients with LC on energy metabolism using indirect calorimetry.

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L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis

Cited by 62 publications

References 11 publications

Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps

Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps

L-carnitine reduces ammonia levels and alleviates covert encephalopathy: A randomized trial

Effect of L-Carnitine in Patients With Liver Cirrhosis on Energy Metabolism Using Indirect Calorimetry: A Pilot Study

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