l-Carnitine attenuates oxidative stress in hypertensive rats

Gómez-Amores, Lucía; Mate, Alfonso; Miguel-Carrasco, José L.; Jiménez, Luís; Jos, Ángeles; Cameán, Ana M.; Revilla, Elisa; Santa-María, Consuelo; Vázquez, Carmen M.

doi:10.1016/j.jnutbio.2006.10.004

Cited by 53 publications

(27 citation statements)

References 44 publications

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“…Many studies propose that vitamin E and L-carnitine have an antioxidant effect and that they sweep free radicals away [5,6,21,[27][28][29][30]. Vitamin E and L-carnitine protect the cell from peroxidative stress by inhibiting the formation of reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, L-carnitine serves an important role in mitochondrial and peroxisomal metabolism [4,5]. In the studies conducted by Gomez-Amores et al [6] and Sushamakumari et al [7], it was observed that L-carnitine cleansed the free radicals and protected the cells against oxygen radicals. In a study conducted by Thangasamy et al [8], for aged rats that were administered L-carnitine, the macromolecules (DNA, proteins, lipids) within the cell were protected against oxidative stress by increases in the antioxidant enzyme and glutathione levels and by reduction in the lipid peroxide levels.…”

Section: Introductionmentioning

confidence: 99%

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Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

2014

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

2014

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“…Carnitine also suppresses oxidative stress by chelating free Fe 2+ ion and activating antioxidants [9]. The antioxidant efficacy of carnitine treatment has been reported in various conditions such as hypertension, hypercholesterolemia, atherosclerosis, or aging that increase systemic oxidative stress [10][11][12][13]. Thus, carnitine can prevent AGE accumulation in tissues and organs by reducing oxidative stress and improving glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Decreased level of serum carnitine might lead to arteriosclerosis progression via the accumulation of advanced glycation end products in maintenance hemodialysis patients

et al. 2017

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Background: Carnitine is reported to improve insulin resistance and reduce oxidative stress. Hyperglycemia and increased oxidative stress are well known to promote the production of advanced glycation end products (AGEs) that can lead to arteriosclerosis in patients with maintenance hemodialysis (HD). In the present study, we aimed to determine whether decreased level of serum carnitine accelerated arteriosclerosis and to clarify the relationships between carnitine, AGEs, and arteriosclerosis in HD patients. Methods: We recruited 116 patients (65 men and 51 women, 62 ± 13 years) undergoing HD three times a week. We measured pre-HD serum free carnitine prior to the first weekly session. AGE level was quantitatively evaluated by measuring skin autofluorescence (SAF) with AGE reader. Arteriosclerosis was evaluated by measuring carotid intima-media thickness (cIMT). Relationships between free carnitine, SAF, and cIMT were analyzed, and significant limiting factors for arteriosclerosis were identified using univariate and multivariate regression analyses. Results: Free carnitine ranged from 14.9 to 53.3 μmol/L (mean, 28.6 ± 8.1 μmol/L). Free carnitine was negatively correlated with SAF (r = − 0.223, P = 0.017) and cIMT (r = − 0.252, P = 0.006). SAF was positively correlated with cIMT (r = 0.263, P = 0.005). Free carnitine was identified as a significant independent limiting factor for cIMT (β = -0.194, P = 0.037). Conclusions: Decreased level of serum carnitine might lead to the progression of arteriosclerosis via the AGE accumulation in HD patients.

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“…It protects the cells from apoptosis and improves much of the mechanisms of physiological antioxidants [38,39]. Antioxidant properties of L-carnitine appears clearly in more than one mechanism, for example decreasing the production of ROS [40,41], maintenance and protection of antioxidant enzymes (SOD, CAT and glutathione peroxidase) [42] Lcarnitine has a potent scavenger capacity for free radicals [43,44].…”

Section: Introductionmentioning

confidence: 99%

Effect of L-carnitine on Lead-induced Infertility in Female Rats

2016

IJSR

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Abstract:The correlation between lead toxicity and infertility was confirmed in many studies. The present study aimed to explore the effect of L-carnitine on the adverse effects caused by lead metal on female rat fertility. Animals were organized into four groups (negative control group, lead acetate positive control group (50mg/L), L-carnitine low dose group (50mg/Kg Bwt/day) and L-carnitine high dose group (100mg/Kg Bwt/day). After 21 day period of treatment blood samples were collected and female rat ovaries were excised for Estradiol quantitative estimation and CYP19a1 gene expression respectively, samples were collected related to the four phases of the estrous cycle. The results of the present study revealed that lead metal in a dose of (50mg/L) causes significant decreases (p<0.05) of CYP19a1 gene expression and estradiol hormone level. L-carnitine have an outstanding beneficial effects on the previous two parameters which increased by increasing the dose. Therefore, the potential of using L-carnitine to combat lead metal adverse effects on female infertility is very promising.

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l-Carnitine attenuates oxidative stress in hypertensive rats

Cited by 53 publications

References 44 publications

Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

Decreased level of serum carnitine might lead to arteriosclerosis progression via the accumulation of advanced glycation end products in maintenance hemodialysis patients

Effect of L-carnitine on Lead-induced Infertility in Female Rats

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