l-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation☆

Chao, Hung-Hsing; Chen, Cheng Hsien; Liu, Ju Chi; Lin, Jia Wei; Wong, Kar‐Lok; Cheng, Tzu-Hurng

doi:10.1016/j.jnutbio.2009.03.003

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…Chao et al (2010) showed that 0.1, 1, and 10 μM resveratrol were neuroprotective in SH-SY5Y cells as shown by lactic dehydrogenase release, caspase-3 activity, and also by JNK and mTOR pathway studies. In another study in the same cell line, a 50 μM concentration was shown to reduce cellular death by inhibiting the activation of caspase 7 and the degradation of PARP (Nicolini et al, 2001).…”

Section: Administration Doses Routes and Bioavailability Of Resveramentioning

confidence: 99%

Resveratrol: French Paradox Revisited

et al. 2012

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Resveratrol is a polyphenol that plays a potentially important role in many disorders and has been studied in different diseases. The research on this chemical started through the “French paradox,” which describes improved cardiovascular outcomes despite a high-fat diet in French people. Since then, resveratrol has been broadly studied and shown to have antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic effects, with those on oxidative stress possibly being most important and underlying some of the others, but many signaling pathways are among the molecular targets of resveratrol. In concert they may be beneficial in many disorders, particularly in diseases where oxidative stress plays an important role. The main focus of this review will be the pathways affected by resveratrol. Based on these mechanistic considerations, the involvement of resveratrol especially in cardiovascular diseases, cancer, neurodegenerative diseases, and possibly in longevity will be is addressed.

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Section: Administration Doses Routes and Bioavailability Of Resveramentioning

confidence: 99%

Resveratrol: French Paradox Revisited

et al. 2012

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“…First, agonists of peroxisome-proliferator-activated receptor gamma (PPARγ), such as those used to treat type 2 diabetes (Salvado et al 2012), have been shown to induce SK1 expression and activity leading to increased S1P levels (Chao et al 2010). Also implicated in regulation of the pathway are thrombin and its receptor, PAR-1.…”

Section: Miscellaneousmentioning

confidence: 99%

Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

Gandy

Obeid

2013

Sphingolipids in Disease

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Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites. The sphingosine kinase/ sphingosine 1-phosphate pathway was originally thought to function in the irreversible breakdown of sphingoid bases; however, in the last few decades it has materialized as an extremely important signaling pathway involved in a plethora of cellular events contributing to both normal and pathophysiological events. Recognition of the SK/S1P pathway as a second messaging system has aided in the identification of many mechanisms of its regulation; however, a cohesive, global understanding of the regulatory mechanisms controlling the SK/S1P pathway is lacking. In this chapter, the role of the SK/S1P pathway as a second messenger is discussed, and its role in mediating TNF-α- and EGF-induced biologies is examined. This work provides a comprehensive look into the roles and regulation of the sphingosine kinase/ sphingosine 1-phosphate pathway and highlights the potential of the pathway as a therapeutic target.

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