l-carnitine and carnitine ester transport in the rat small intestine

Marciani, P.; Lindi, C.; Marzo, A; Martelli, E. Arrigoni; Cardace, G.; Esposito, Giovanni

doi:10.1016/s1043-6618(05)80117-3

Cited by 17 publications

(9 citation statements)

References 6 publications

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“…Quite interestingly, 13 C atoms derived from Asp degradation are observed on purine metabolism product AXP and GXP from the first sampled time point to the last, despite the gluconeogenic metabolism precursor PEP does not display the same signal. We thus argue that the origin of Asp-derived labelling on AXP and GXP might be due to TCA intermediates playing a role in purine metabolism, e.g., 5phosphoribosylamine, Finally, we confirmed the late entrance of Met into PhTAC125 metabolic network, being initially converted to homocysteine and then also rerouted towards the production of trimethylamine (at T24), with a possible but still undisclosed pathway involving the formation of betaine or carnitine [34][35][36] .…”

Section: Resultssupporting

confidence: 65%

Diauxie and co-utilization of carbon sources can coexist during bacterial growth in nutritionally complex environments

et al. 2020

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It is commonly thought that when multiple carbon sources are available, bacteria metabolize them either sequentially (diauxic growth) or simultaneously (co-utilization). However, this view is mainly based on analyses in relatively simple laboratory settings. Here we show that a heterotrophic marine bacterium, Pseudoalteromonas haloplanktis, can use both strategies simultaneously when multiple possible nutrients are provided in the same growth experiment. The order of nutrient uptake is partially determined by the biomass yield that can be achieved when the same compounds are provided as single carbon sources. Using transcriptomics and time-resolved intracellular 1 H-13 C NMR, we reveal specific pathways for utilization of various amino acids. Finally, theoretical modelling indicates that this metabolic phenotype, combining diauxie and co-utilization of substrates, is compatible with a tight regulation that allows the modulation of assimilatory pathways.

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Section: Resultssupporting

confidence: 65%

Diauxie and co-utilization of carbon sources can coexist during bacterial growth in nutritionally complex environments

et al. 2020

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“…All three of them are available commercially and are known for their ability to increase plasma and brain carnitine levels, improve mitochondrial dysfunction, and ameliorate energy level. Although some authors suggested that carnitine esters (acetyl-l-carnitine and proprionyl-l-carnitine) absorption is better than that of L-carnitine [125], an anti-oxidant effect has been documented for all three. Nonetheless, more research is required to test whether various carnitine compounds are interchangeable.…”

Section: Carnitinementioning

confidence: 99%

Fatigue in multiple sclerosis – Insights into evaluation and management

Ayache

Chalah

2017

Neurophysiologie Clinique/Clinical Neurophysiology

126

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“…It also acts reducing the intramitochondrial ratio of acetyl‐CoA to free CoA, thus stimulating the activity of pyruvate dehydrogenase complex to facilitate glucose oxidation. Acetyl‐L‐carnitine (ALC), one of the carnitine derivatives, possesses similar physiological function but better bioavailability and antioxidant capacity compared with carnitine [9,10]. On the other hand, oxfenicine (OXF) is a well‐characterized CPT‐1 inhibitor that can reduce the accumulation of long‐chain acyl‐carnitine to enhance glucose metabolism [11], whereas the lowering of long‐chain fatty acyl groups is less pronounced [12,13].…”

Section: Introductionmentioning

confidence: 99%