L’atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d’un cas

Abstract

Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive.

Metastatic Kaposi sarcoma in a non-HIV patient leading to metacarpal lysis then upper-limb amputation: a case report

“…reported a patient with isolated KS in the finger with bone involvement but no cutaneous lesion upon clinical examination [ 14 ]. One report did concern classic KS leading to osteolysis in the hand that required amputation, however the patient was over 100 years of age and of Moroccan origin [ 15 ]. Classic Kaposi’s disease, unlike the endemic form, does generally occur in older patients (more than 75 years of age), and yet our patient developed the disease in early age.…”

Yield of FDG PET/CT for Defining the Extent of Disease in Patients with Kaposi Sarcoma

“…Four types of KS are described: classic (sporadic or Mediterranean), endemic (African), epidemic (or HIV-related), and iatrogenic (induced by immunosuppressive drugs) [1][2][3][4]. It mostly involves the skin (especially in distal limbs), but the KS extension to deeper structures such as bone and joints can be destructive and lead to severe functional impairment [5]. Musculoskeletal involvement is mostly seen in endemic and HIV-related KS [6].…”

“…Musculoskeletal involvement is mostly seen in endemic and HIV-related KS [6]. Visceral lesions are rare in immunocompetent patients but can be rapidly progressive and life-threatening in immunocompromised patients [3,5]. Gastrointestinal involvement is the most common visceral site, involved in 40-51% of untreated HIV-related KS, and can induce severe gastrointestinal bleeding [4,7].…”