L‐asparaginase isolated fromStreptomyces ansochromogenespromotes Th1 profile and activatesCD8⁺T cells in humanPBMC: anin vitroinvestigation

Abstract

L-asparaginase is an indispensable component of the chemotherapeutic treatment of acute lymphoblast leukaemia (ALL) and acute myeloid leukaemia (AML). Currently, drugs such as Asparaginase , Kidrolase , and Elspar and Erwinase are efficient against leukemic disease, but promote immunosuppression and other side effects in human organisms. Our purified S. ansochromogenes L-asparaginase showed promissory results inducing, in vitro, higher immunostimulation in human PBMC, especially in T CD8 lymphocyte subsets.