L-Ascorbic Acid in Organic Synthesis: An Overview

The Suzuki Cross-Coupling Reaction of l-Ascorbic Acid: C2-Aryl­ation and Evaluation as Antiproliferative Agents

“…Optical rotations were recorded on Jasco DIP Digital 181 Polarimeter at 25 °C. 1 H and 13 C NMR were recorded on Varian Mercury/Bruker Avance 300/500 and 75/125 MHz, respectively, in CDCl 3 solution with TMS as internal reference. HRMS were performed with a QTOF Micromass mass spectrometer by ESI mode.…”

“…Applications of L-ascorbic acid in organic synthesis have gained impetus in recent years resulting in the synthesis of different molecules of biological importance and chemotherapeutic significance. 1 The alkylation of L-ascorbic acid has been studied in detail and conditions for both O-and C-alkylation have been identified. 2 Recently, we have shown that 2,3-di-O-alkyl derivatives of L-ascorbic acid exhibit enhanced cytotoxic activity compared to L-ascorbic acid.…”

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

“…Furthermore, they can also be classified as reducing or nonreducing sugars. L-ascorbic acid (3), a very important naturally occurring molecules can be placed in the category of six carbon containing sugar [20]. Sialic acids contain a 9carbon backbone and are more structurally complex molecules as compared to five-or six-carbon monosaccharides, but known for the most important recognition elements as terminal sugars [21].…”

“…Erythromycin (10) exerts antibacterial activity through inhibition of protein synthesis by binding to peptidyltransferase site of 50S subunit [31]. Among other derivatives, cethromycin (19), EP-420 (20) and BAL-19403 (21) are currently in clinical development [32]. Cethromycin (19) has demonstrated clinically and statistically significant survival rate in placebo-controlled non-human primate studies with anthrax, plague and tularemia.…”

An innovative strategy for the production of novel magnetite poly(vinyl alcohol) nanocomposite films with double-capped synthesized Fe3O4nanoparticles with citric acid and vitamin C

“…AS has four hydroxyl groups that can act as a ligand to metal oxides in order to protect NPs from agglomeration. [10][11][12][13] The agglomeration of the NPs with high surface energies by virtue of their size is one of the most challenging problems for fabricating nanocomposites (NC)s. Grafting of organic molecules on the NPs surface is a useful strategy for improving the dispersion and preventing agglomeration. Moreover, magnetic NPs are high chemically active, easily oxidized in air leading to reduced magnetic characterization, while by protection strategy with organic capping agents may solve these problems.…”