l-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women

Aguiar, Andreo Fernando; Balvedi, Mario Carlos Welin; Buzzachera, Cosme Franklim; Altimari, Leandro Ricardo; Lozovoy, Marcell Alysson Batisti; Bigliassi, Marcelo; Januário, Renata Selvatici Borges; Pereira, Rafael Mendes; Sanches, Vanda Cristina; Silva, Douglas Kratki da; Muraoka, Guilherme Atsushi

doi:10.1007/s00394-015-1019-6

Cited by 17 publications

(13 citation statements)

References 64 publications

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“…For example, Greer and investigators [ 637 ] examined the ability of arginine + alpha-ketoglutarate and reported that the combination did not significantly impact muscle endurance and significantly reduced the number of chin-ups completed. Similar outcomes were found by Aguiar et al [ 638 ] in older women whereby arginine supplementation failed to impact muscle performance. Sunderland et al [ 639 ] supplemented 18 endurance-trained cyclists for 28 days with either arginine (12 g/day) or corn starch and concluded that arginine did not impact VO 2 Max or ventilatory threshold.…”

Section: Introductionsupporting

confidence: 87%

ISSN exercise & sports nutrition review update: research & recommendations

Kerksick

Wilborn

Roberts

et al. 2018

Journal of the International Society of Sports Nutrition

601

741

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BackgroundSports nutrition is a constantly evolving field with hundreds of research papers published annually. In the year 2017 alone, 2082 articles were published under the key words ‘sport nutrition’. Consequently, staying current with the relevant literature is often difficult.MethodsThis paper is an ongoing update of the sports nutrition review article originally published as the lead paper to launch the Journal of the International Society of Sports Nutrition in 2004 and updated in 2010. It presents a well-referenced overview of the current state of the science related to optimization of training and performance enhancement through exercise training and nutrition. Notably, due to the accelerated pace and size at which the literature base in this research area grows, the topics discussed will focus on muscle hypertrophy and performance enhancement. As such, this paper provides an overview of: 1.) How ergogenic aids and dietary supplements are defined in terms of governmental regulation and oversight; 2.) How dietary supplements are legally regulated in the United States; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of nutritional approaches to augment skeletal muscle hypertrophy and the potential ergogenic value of various dietary and supplemental approaches.ConclusionsThis updated review is to provide ISSN members and individuals interested in sports nutrition with information that can be implemented in educational, research or practical settings and serve as a foundational basis for determining the efficacy and safety of many common sport nutrition products and their ingredients.

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Section: Introductionsupporting

confidence: 87%

ISSN exercise & sports nutrition review update: research & recommendations

Kerksick

Wilborn

Roberts

et al. 2018

Journal of the International Society of Sports Nutrition

601

741

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“…First, L-arg supplementation may be ineffective to increase NO production and, consequently, muscle blood flow at rest and exercise conditions in healthy individuals. This hypothesis is supported by several studies involving healthy individuals that showed no additional effect of Larg supplementation (range: 6 -10 g) on NO production (measured by NO 2 and NO 3 -) (Blum et al 2000;Evans et al 2004;2012a;Liu et al 2009;Koppo et al 2009;Tang et al 2011) and blood flow (Blum et al 2000;Tang et al 2011;Aguiar et al 2016), despite increases in plasma L-arg concentration (Blum et al 2000;Evans et al 2004;Liu et al 2009;Tang et al 2011;2012a). This is consistent with fact that physiological concentrations of Larg (range: 40 to 100 µmol•L -1 ) in healthy individuals are sufficient to saturate endothelial nitric oxide synthase, which is ∼2-20 µmol•L -1 (Durante et al 2007), resulting in no additional effect on NO production.…”

Section: Discussionmentioning

confidence: 75%

l-Arginine supplementation does not improve muscle function during recovery from resistance exercise

Andrade

Jacinto

Silva

et al. 2018

Appl. Physiol. Nutr. Metab.

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The purpose of this study was to investigate the effects of l-arginine supplementation on muscle recovery after a single session of high-intensity resistance exercise (RE). Twenty healthy young adult participants (22.8 ± 3.4 years old) were assigned to 1 of 2 groups (N = 10 per group): a placebo-supplement group or an l-arginine-supplement group. The groups completed a session of high-intensity RE (0 h) and 3 subsequent fatigue test sessions (at 24, 48, and 72 h postexercise) to assess the time course of muscle recovery. During the test sessions, we assessed the following dependent variables: number of maximum repetitions, electromyographic signal (i.e., root mean square (RMS) and median frequency (MF) slope), muscle soreness, perceived exertion, blood levels of creatine kinase (CK) and lactate, and testosterone:cortisol ratio. Number of maximum repetitions increased at 48 and 72 h postexercise in both groups (time, P < 0.05). CK levels and muscle soreness increased at 24 h postexercise and then progressively returned to baseline at 72 h post exercise in both groups (time, P < 0.05). Lactate levels increased immediately postexercise but were reduced at 24 h postexercise in both groups (time, P < 0.05). Testosterone:cortisol ratio, RMS, and MF slope remained unchanged during the recovery period in both groups (time, P > 0.05). No significant (P > 0.05) group × time interaction was found for all dependent variables during the recovery period. In conclusion, our data indicate that l-arginine supplementation does not improve muscle recovery following a high-intensity RE session in young adults.

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“…When ADMA levels are low, eNOS flux is near the V max at physiologic arginine levels . Consequently, clinical studies of l _arginine in healthy individuals generally fail to show beneficial effects on blood flow . Similarly, clinical trials using l _arginine in primary RP consistently demonstrate no appreciable effect .…”

Section: Effects Of Adma In Raynaud's Phenomenon and L_arginine Treatmentioning

confidence: 99%

“…61 Consequently, clinical studies of L-arginine in healthy individuals generally fail to show beneficial effects on blood flow. 34,[62][63][64][65] Similarly, clinical trials using L-arginine in primary RP consistently demonstrate no appreciable effect. 66,67 Whether or not there is a long-term protective effect of arginine supplementation in these patients is speculative and beyond the scope of this article.…”

Section: Effects Of Adma In Raynaud's Phenomenon and L-arginine Treatmentioning

confidence: 99%

The clinical effects of l_arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon

Curtiss

Schwager

Sicco

et al. 2018

Acad Dermatol Venereol

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Secondary Raynaud's phenomenon (RP) is often the sentinel clinical finding in systemic sclerosis and may precede systemic disease by several years. Altered nitric oxide metabolism plays a critical role in both fibrosis and severe secondary RP phenotypes in these patients. Increased flux through inducible nitric oxide synthase (iNOS) drives cutaneous fibrosis. Failure of flux through endothelial nitric oxide synthase (eNOS) contributes to increased vasoconstriction and decreased vasorelaxation. The underproduction of nitric oxide by eNOS is in part due to increased levels of asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase. The inhibitory effects of increased ADMA levels may be counteracted increasing serum l-arginine, which is often an effective treatment strategy in these patients. As such, l-arginine-based therapies should be considered in managing secondary RP, particularly given their favourable safety and tolerability profile. While there is no established dosing regimen, studies of oral l-arginine in secondary RP suggest that divided dosing may begin at 1-2 g/day and may be titrated up to 10 g/day. Conversely, primary RP is not associated with increased ADMA production which likely accounts for the failure of l-arginine trials to show benefit in primary RP.

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l-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women

Abstract: These results show that acute L-arg supplementation provides no ergogenic effect on blood flow and muscle performance in older women.

Cited by 17 publications

References 64 publications

ISSN exercise & sports nutrition review update: research & recommendations

ISSN exercise & sports nutrition review update: research & recommendations

l-Arginine supplementation does not improve muscle function during recovery from resistance exercise

The clinical effects of l_arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon

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