l-Arginine supplementation blunts resistance exercise improvement in rats with chronic kidney disease

Souza, Michel Kendy; Moraes, Milton Rocha; Rosa, Thiago Santos; Passos, Clévia Santos; Neves, Rodrigo Vanerson Passos; Haro, Anderson Sola; Cenedeze, Marcos Antônio; Arias, Simone Costa Alarcon; Fujihara, Clarice Kazue; Teixeira, Simone Aparecida; Muscará, Marcelo Nícolas; Câmara, Niels Olsen Saraiva; Filho, Álvaro Pacheco e Silva

doi:10.1016/j.lfs.2019.116604

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…It is also speculated that Arg supplementation provided an excess of nitrogen, deteriorating renal function and leading to an increase in reactive oxygen species. Therefore, Arg supplementation does not appear to be beneficial in CDK [53].…”

Section: Supplementation With Argmentioning

confidence: 94%

Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation

Maykish

Sikalidis

2020

JPM

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While onset characteristics may vary, sarcopenia gradually develops over time as a result of the aging process, leading to muscle loss, disturbance of the muscle to fat ratio, and a variety of negative symptoms undermining the wellbeing, quality of life, and lifespan in the aging population globally. There is evidence that sarcopenia may be a cause and consequence of type 2 diabetes mellitus (T2DM) in the aging population. The importance of nutritional management in the prevention and/or deceleration of sarcopenia is critical, with the main focus placed on the amount and quality of protein intake. Significant efforts are being made towards the development of medical nutrition therapies involving certain amino acids and amino compounds, as well as their combinations, for the improvement in muscle strength, muscle function and protein synthesis. This may reduce hospitalization times and hasten the recovery of patients with sarcopenia. The administration of protocols with varying dose and frequencies, as well as their efficacy, is being investigated. In the work herein, we present and evaluate data derived from human trials regarding the utilization of hydroxyl-methyl butyrate (HMB), L-leucine (Leu), L-glutamine (Gln) and L-arginine (Arg) supplementation for optimal management of sarcopenia in geriatric patients, a topic of significant clinical nutrition interest which may have important implications in T2DM status.

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Section: Supplementation With Argmentioning

confidence: 94%

Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation

Maykish

Sikalidis

2020

JPM

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“…The hydrolysate peptides from S. nudus L. exhibited remarkable scavenging activities against superoxide anions, DPPH radicals, and hydroxyl radicals, along with notable ACE inhibitory activity and in vitro antitumor properties [ 21 ]. Studies have shown that amino acids, such as Ser, Arg, and Pro, can improve renal dysfunction and reduce renal disease [ 22 , 23 , 24 ]. Peptides rich in Ser, Arg, and Pro exhibit good anti-Cd and nephroprotective effects [ 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

A Tripeptide (Ser-Arg-Pro, SRP) from Sipunculus nudus L. Improves Cadmium-Induced Acute Kidney Injury by Targeting the MAPK, Inflammatory, and Apoptosis Pathways in Mice

Pan,

Peng,

Fang

et al. 2024

Marine Drugs

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Cadmium (Cd) is a toxic heavy metal that causes nephrosis, including acute kidney injury. To prevent and treat acute kidney injury (AKI) following Cd exposure, a tripeptide, Ser-Arg-Pro (SRP), from Sipunculus nudus L. was employed, and its potential efficacy in AKI was assessed. Oral administration of SRP significantly alleviated Cd-induced kidney damage, leading to improved renal function and the attenuation of structural abnormalities. A network pharmacology analysis revealed the potential of SRP in renal protection by targeting various pathways, including mitogen-activated protein kinase (MAPK) signaling, inflammatory response, and apoptosis pathways. Mechanistic studies indicated that SRP achieves renal protection by inhibiting the activation of MAPK pathways (phosphorylation of p38, p56, ERK, and JNK) in the oxidative stress cascade, suppressing inflammatory responses (iNOS, Arg1, Cox2, TNF-α, IL-1β, and IL-6), and restoring altered apoptosis factors (caspase-9, caspase-3, Bax, and Bcl-2). Hence, SRP has the potential to be used as a therapeutic agent for the treatment of Cd-induced nephrotoxicity.

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Nanoliposomal amino acids counteracting protein malnutrition induced hematopoietic and hepatic complications

Ahmed,

Elbaset,

Farouk

et al. 2023

Journal of Drug Delivery Science and Technology

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l-Arginine supplementation blunts resistance exercise improvement in rats with chronic kidney disease

Cited by 4 publications

References 47 publications

Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation

Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation

A Tripeptide (Ser-Arg-Pro, SRP) from Sipunculus nudus L. Improves Cadmium-Induced Acute Kidney Injury by Targeting the MAPK, Inflammatory, and Apoptosis Pathways in Mice

Nanoliposomal amino acids counteracting protein malnutrition induced hematopoietic and hepatic complications

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