l-Arginine supplementation 0.5% of diet during the last 90 days of gestation and 14 days postpartum reduced uterine fluid accumulation in the broodmare

Mesa, Ana M.; Warren, L.K.; Sheehan, Jacqueline; Kelley, Dale E.; Mortensen, C.J.

doi:10.1016/j.anireprosci.2015.05.011

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…Amino acids are biological activity regulators of physiological systems such as the reproductive, cardiovascular, and immune systems of animals 28 . L-arginine can alter pituitary function and increase blood flow to the reproductive tract, providing nutrients or other substances for follicular development and has important implications for gestational development in the uterus 29,30 . In gilts (young female pigs), oral supplementation with L-arginine from day 30 of pregnancy increases litter size and birth weight 31 .…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic and pituitary transcriptome profiling using RNA-sequencing in high-yielding and low-yielding laying hens

Wang

2019

Sci Rep

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The reproductive physiology and laying performance of laying hens are regulated by the hypothalamus and pituitary. To understand the mechanism of egg laying regulation, we sequenced and analysed the hypothalamus and pituitary expression profiles in high- and low-yielding laying Chinese Dagu Chickens (CDC) using RNA-seq. More than 46 million clean reads and 24,873 tentative genes were obtained using the Gallus gallus genome as a reference. Transcriptome analysis in hypothalamus and pituitary revealed seven and 39 differentially expressed genes (DEGs) between high- and low-yielding CDC hens, respectively. A total of 24 and 22 DEGs were up-regulated and down-regulated, respectively, and 13 novel genes were identified. Functional annotation and pathway enrichment analysis showed that DEGs in the hypothalamus were mainly enriched in glycosaminoglycan biosynthesis. DEGs significantly enriched in the pituitary primarily affected the extracellular matrix, the protein extracellular matrix, and the extracellular space. Pathways involving phenylalanine metabolism, 2-oxocarboxylic acid metabolism, the glycosphingolipid biosynthesis-ganglion series, and local adhesion were significantly enriched in the pituitary. Eight DEGs, PRDX6 , TRIB2 , OVCH2 , CFD , Peptidase M20 , SLC7A10 , and two other amino acid transporters, are involved in the metabolism and transport of amino acids. To our knowledge, this is the first study comparing the hypothalamus and pituitary transcriptomes of high- and low-yielding laying hens. Our findings suggest that putative differences in gene expression can provide a base for further research in this field. Moreover, we identified increased expression of genes involved in amino acid metabolism, glycosaminoglycan biosynthesis, and oestrogen negative feedback systems in low-yielding laying hens, highlighting their potential as biomarkers of egg production.

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Section: Discussionmentioning

confidence: 99%

Hypothalamic and pituitary transcriptome profiling using RNA-sequencing in high-yielding and low-yielding laying hens

Wang

2019

Sci Rep

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“…As a result, primiparous mares supplemented with L-arginine received more crude proteins than primiparous control mares. In another study performed in the horse, additional crude protein provided by L-arginine supplementation was normalized in the control group using urea 27 . In that study, L-arginine supplementation reduced uterine fluid accumulation after foaling in mares.…”

Section: Discussionmentioning

confidence: 99%

“…The few studies conducted in horses did not demonstrate any effect of L-arginine supplementation on foal birthweight but the possible interaction between L-arginine supplementation and maternal parity was not examined 27–29 .…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth

Robles

Couturier-Tarrade

Derisoud

et al. 2019

Sci Rep

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Foals born to primiparous mares are lighter and less mature than those born to multiparous dams. Factors driving this difference are not totally understood. Using 7 multiparous and 6 primiparous standardbred mares, we demonstrated that, in late gestation, primiparous mares were less insulin resistant compared to multiparous mares, and that their foals had reduced plasma amino-acid concentrations at birth compared to foals born to multiparous mares. Vascular development, as observed through structure and gene expression, and global DNA methylation were also reduced in primiparous placentas. Another group of 8 primiparous mares was orally supplemented with L-arginine (100 g/day, 210d to term). L-arginine improved pregnancy-induced insulin resistance and increased maternal L-arginine and L-ornithine plasma concentrations but foal plasma amino acid concentrations were not affected at birth. At birth, foal weight and placental biometry, structure, ultra-structure and DNA methylation were not modified. Placental expression of genes involved in glucose and fatty acid transfers was increased. In conclusion, maternal insulin resistance in response to pregnancy and placental function are reduced in primiparous pregnancies. Late-gestation L-arginine supplementation may help primiparous mares to metabolically adapt to pregnancy and improve placental function. More work is needed to confirm these effects and ascertain optimal treatment conditions.

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“…Dietary arginine supplementation in mares during the last 4 months of pregnancy increased foal weight at birth compared to control animals (Chavatte‐Palmer et al, ). Feeding arginine during the last days of pregnancy accelerated expulsion of fluid from the post‐partum uterus (Kelley, Warren, & Mortensen, ) and reduced the incidence of mating‐induced endometritis when mares were bred again after foaling (Mesa, Warren, Sheehan, Kelley, & Mortensen, ). Supplementing the feed of mares with arginine for 3 weeks before the expected date of foaling shortened gestation length and increased uterine arterial blood flow before and after parturition (Mortensen, Kelley, & Warren, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary L‐arginine supplementation to early pregnant mares on conceptus diameter—Preliminary findings

Aurich

Köhne

Wulf³

et al. 2019

Reprod Domestic Animals

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ContentsThe importance of the amino acid L‐arginine (ARG) for conceptus growth and litter size has been demonstrated in various species. L‐arginine is part of embryo‐derived polyamines, a substrate for nitric oxide synthase and stimulates protein synthesis by the embryo. In the present study, we have investigated whether dietary L‐arginine supplementation stimulates early conceptus growth in mares. Warmblood mares with singleton pregnancies received either an arginine‐supplemented diet (approximately 0.0125% of body weight, n = 12) or a control diet (n = 11) from days 15 to 45 after ovulation. Diameter of the embryonic vesicle (days 14, 17, 20 of pregnancy) and size of the embryo respective foetus (length and maximal diameter, days 25–45 of pregnancy at 5‐day intervals) were determined by transrectal ultrasound. At foaling, weight and size of the foal and the placenta were determined. Blood for determination of equine chorionic gonadotrophin (eCG) and progestin concentrations was collected repeatedly. Neither eCG nor progestin concentration in plasma of mares differed between groups at any time. No effects of arginine treatment on diameter of the embryonic vesicle between days 14 and 20 of pregnancy were detected. Diameter of the embryo/foetus on days 40 to 45 of pregnancy strongly tended to be enhanced by arginine supplementation (p = 0.06). Weight and size of neither the foal nor placenta at birth differed between groups. In conclusion, L‐arginine supplementation was without negative effects on early equine embryos and may support embryonic growth at the beginning of placentation.

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l-Arginine supplementation 0.5% of diet during the last 90 days of gestation and 14 days postpartum reduced uterine fluid accumulation in the broodmare

Cited by 11 publications

References 29 publications

Hypothalamic and pituitary transcriptome profiling using RNA-sequencing in high-yielding and low-yielding laying hens

Hypothalamic and pituitary transcriptome profiling using RNA-sequencing in high-yielding and low-yielding laying hens

Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth

Effects of dietary L‐arginine supplementation to early pregnant mares on conceptus diameter—Preliminary findings

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