L-Arginine Modulates Intestinal Inflammation in Rats Submitted to Mesenteric Ischemia-Reperfusion Injury

Taha, Murched Omar; Oliveira, Julyane Vasconcelos; Borges, Mariana Eiras; Melo, Florence de Lucca; Gualtieri, Fabio; Aidar, Ana Laura E Silva; Pacheco, Rafael Leite; Silva, T. de Melo Alexandre e; Klajner, Rafael Kogan; Iuamoto, Leandro Ryuchi; Torres, Leonardo M.; Paula, B.J. Morais Mendes de; Campos, Karis de; Oliveira, Indhira Dias; Fagundes, Djalma José

doi:10.1016/j.transproceed.2015.12.063

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…In weaned pigs, arginine suppressed inflammatory response in lipopolysaccharide‐treated ileum by increasing the numbers of IgA‐secreting cells, CD8 + and CD4 + T cells and preventing the elevation of mast cell numbers (Zhu, Liu, Xie, Huang & Hou, ). Additionally, arginine alleviated the intestinal inflammatory response in rats with intestinal ischaemia and reperfusion (Taha et al., ). In vitro study with Caco‐2 cells also showed that arginine prevented the methotrexate‐induced barrier disruption by increasing the expression of tight junction proteins (Beutheu, Ghouzali, Galas, Déchelotte & Coëffier, ).…”

Section: Introductionmentioning

confidence: 99%

Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot,Scophthalmus maximusL.

Chen

Liu

et al. 2018

Aquac Res

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A 12‐week feeding trial was conducted to investigate the protective effects of arginine on the intestinal health of juvenile turbot (Scophthalmus maximus L.) fed high doses of dietary soybean meal. Sextuple replicates of 30 fish were fed each of four isonitrogenous and isolipidic experimental diets: fish‐meal‐based diet (FM); FM with 40% fish meal protein replaced by soybean meal protein (SBM); SBM+1% arginine (ARG1) and SBM+2% arginine (ARG2). Turbot‐fed SBM showed typical soybean meal‐induced enteropathy, characterized by an increase in the thickness of lamina propria, as well as significant decreases in the absorptive surface and activities of intestinal brush border membrane enzymes and Na+, K+‐ATPase. On the contrary, fish‐fed ARG1 showed enhanced intestinal mucosal barrier function in terms of the enhanced gene expression of anti‐inflammatory cytokine and barrier‐forming tight junction proteins, as well as depressed gene expression of pro‐inflammatory cytokines and pore‐forming tight junction proteins. Fish‐fed AGR2 showed intermediate intestinal performances between SBM and AGR1. Dietary arginine (1%) also significantly regulated the expression of AMP‐activated protein kinase α1 (AMPKα1), myosin light chain kinase (MLCK) and nuclear transcription factor‐κB p65 (NF‐κB p65), and these regulations correlated well with its regulations on intestinal mucosal barrier related genes at all sampling time‐points. In conclusion, arginine supplementation (1%) in diet for turbot mitigated the soybean meal‐induced enteropathy by enhancing the intestinal mucosal barrier function. The activation of AMPKα1 signalling molecule as well as the suppression of NF‐κB p65 and MLCK signalling molecules may mediate the beneficial effects of arginine.

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Section: Introductionmentioning

confidence: 99%

Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot,Scophthalmus maximusL.

Chen

Liu

et al. 2018

Aquac Res

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“…Oral creatine supplementation is related to an increase in the working capacity of skeletal muscles, delaying the onset of muscle fatigue 9 . This is due to the energy supplied through the Cr/ATP/CK system, which can promote protection against cell damage caused by ischemia in various organs, such as the kidneys, lungs, heart, brain, intestine and testicles 3 , 6 , 10 , 16 , 17 , 18 .…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary creatine supplementation on kidney and striated skeletal muscles of rats submitted to ischemia and reperfusion of hind limbs

Neto

Moreira

et al. 2021

Acta Cir. Bras.

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To evaluate the effect of creatine supplementation in the diet of rats subjected to ischemia and reperfusion of hind limbs. Methods: Eighteen male Wistar rats were randomized to receive dietary creatine supplementation (G1) or no supplementation (G2), before being subjected to 4 h of ischemia followed by 4 h of reperfusion. In addition, 10 rats (G3) underwent the same surgical procedure, without ischemia, but with supplementation. After reperfusion, kidney and musculature were evaluated for histological damage and serum levels of alanine aminotransferase, urea and creatinine were obtained. Results: The urea dosage showed significant differences between the groups (averages G1 = 155.1; G2 = 211.27; G3 = 160.42). Histological analysis found significant differences between G1 and G2 (but not between G1 and G3) in renal myoglobin cylinders and vacuolar degeneration variables and in hypereosinophilia and karyopyknosis variables in muscle fibers. There were no significant differences in the other variables studied. Conclusion: Creatine supplementation was related to fewer histological lesions, as well as lower levels of plasma urea, which may suggest a protective effect against lesions caused by ischemia and reperfusion of posterior paws muscles in Wistar rats.

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“…As the substrate for nitric oxide (NO) synthesis, amino acid Arg is reported to be therapeutic in wound healing and has potent anti-inflammatory properties as a mediator of autoimmune diseases [93–96]. Otherwise, exogenous Arg is associated with antiapoptotic effects on the rat intestine and useful in the treatment of intestinal ischemia/reperfusion injury [97]. Dietary supplementation with Arg can improve the immune status of humans and animals and has the potential to be used to supplement current treatments for IBD [12].…”

Section: Amino Acids: Application In Inflammatory Bowel Disease Thmentioning

confidence: 99%

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

Bao

Feng

Yao³

et al. 2017

Mediators of Inflammation

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Inflammatory Bowel Disease (IBD) is a kind of chronic inflammation, which has increasing incidence and prevalence in recent years. IBD mainly divides into Crohn's disease (CD) and ulcerative colitis (UC). It is hard to cure IBD completely, and novel therapies are urgently needed. Amino acids (AAs) and their metabolites are regarded as important nutrients for humans and animals and also play an important role in IBD amelioration. In the present study, the potential protective effects of AAs and their metabolites on IBD had been summarized with the objective to provide insights into IBD moderating using dietary AAs and their metabolites as a potential adjuvant therapy.

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L-Arginine Modulates Intestinal Inflammation in Rats Submitted to Mesenteric Ischemia-Reperfusion Injury

Cited by 4 publications

References 17 publications

Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot,Scophthalmus maximusL.

Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot,Scophthalmus maximusL.

Effects of dietary creatine supplementation on kidney and striated skeletal muscles of rats submitted to ischemia and reperfusion of hind limbs

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

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