L’administration intrathécale de lidocaïne et de sufentanil diminue le temps de récupération après une opération du rectum en chirurgie ambulatoire

Waxler, Beverly; Mondragon, Shirley A.; Patel, Sonal N.; Nedumgottil, Kochuthresia

doi:10.1007/bf03018425

Cited by 15 publications

(15 citation statements)

References 28 publications

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“…In the present study, we asked patients specifically about itching and the incidence of this adverse event in patients exposed to IT sufentanil was approximately 80%, in contrast to 50% in a similar study 4 by our group. However, the two studies may not be entirely comparable because the explanations given to the patients were different.…”

Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 71%

“…In the present study, patients were told that the main purpose of the trial was to test whether ondansetron would prevent itching after spinal anesthesia with lowdose lidocaine and IT sufentanil. In our previous study, 4 patients were told that the main purpose of the study was to compare recovery after two different techniques for spinal anesthesia, warning about possible complications including pruritus. Since pruritus is a sensation, 2,3 its perception may also be influenced by the explanation of the project to the patients.…”

Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 99%

“…Itching after intrathecal (IT) opioids is an undesirable side effect of opioids [1][2][3] which can develop with a frequency ranging between 20 and 80%. 2,4 The mechanisms causing pruritus (and the resultant scratching) are complex 2,3,5 and may involve central or peripheral mechanisms. Central mechanisms of opioid-induced pruritus (either systemically or regionally) are more important clinically than peripheral mechanisms.…”

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confidence: 99%

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L’administration prophylactique d’ondansétron ne réduit pas l’incidence de prurit induit par le sufentanil intrathécal

Waxler

Mondragon

Patel

et al. 2004

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : Postoperative itching after intrathecal (IT) narcotics may be a difficult and important problem for both the anesthesiologist and the patient in the postanesthetic care unit. Since some studies have reported success in preventing itching with ondansetron, we designed a prospective, randomized, double-blinded, and controlled study to test whether prophylactic iv ondansetron effectively reduces the incidence of IT sufentanil-induced pruritus.M Me et th ho od ds s: : Thirty-four patients (ASA I-III, age 18-74 yr) underwent ambulatory surgery after spinal anesthesia with IT lidocaine (15-100 mg) and IT sufentanil (10 µg). The patients were randomized into two groups to receive iv either 4 mL saline (n = 13) or 8 mg ondansetron (n = 21) before the IT injection. The incidence of pruritus and other variables was recorded. Pruritus scores were obtained with a verbal analogue score with 0 meaning none and 10 the worst itching that the patient could imagine. Statistical difference was assumed if P < 0.05. R Re es su ul lt ts s: : Ondansetron did not reduce the incidence of pruritus (77 vs 81%) compared to placebo (P = 1.000). The pruritus scores (4.4 vs 3.6) of the two groups were not significantly different (P = 0.670).C Co on nc cl lu us si io on ns s: : There are contradictory findings in the literature regarding the effectiveness of ondansetron in preventing narcoticinduced itching. Although some studies have indicated that ondansetron could prevent this side effect of IT narcotics, a recent report suggested that ondansetron is not effective in preventing narcotic-induced itching (sufentanil-morphine) after a Cesarean section. In the present study we obtained similar, negative results. Objectif : Le prurit postopératoire induit par l'administration intrathé-cale (IT) de narcotiques est un problème important pour l'anesthésio-logiste et le patient en salle de réveil. Certaines études ont montré que l'ondansétron prévenait le prurit. Notre étude prospective, randomisée, contrôlée et à double insu voulait vérifier si l'administration iv préventive d'ondansétron réduit effectivement l'incidence de prurit induit par le sufentanil IT. Méthode : Trente-quatre patients (ASA I-III, de 18 à 74 ans) ont subi une intervention chirurgicale ambulatoire sous rachianesthésie avec de la lidocaïne IT (15-100 mg) et du sufentanil IT (10 µg). Les patients, randomisée en deux groupes, ont reçu soit 4 mL de solution saline iv (n = 13), soit 8 mg d'ondansétron (n = 21) avant l'injection IT. L'incidence de prurit et d'autres variables a été notée. Les scores de

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Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 71%

Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 99%

mentioning

confidence: 99%

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L’administration prophylactique d’ondansétron ne réduit pas l’incidence de prurit induit par le sufentanil intrathécal

Waxler

Mondragon

Patel

et al. 2004

Can J Anesth/J Can Anesth

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“…Beverly Waxleretal reported itching as a well-known side effect of intrathecal narcotics. 10 Incidence of pruritus was 56% with sufentanil and lignocaine in their study. No respiratory depression was observed.…”

Section: Parametermentioning

confidence: 70%

“…8,9 Waxler et al reported shorter time to ambulation in patients who received intrathecal lignocaine and sufentanil. 10 Lau et al also reported earlier discharge of outpatients on lignocaine and sufentanil who underwent extracorporeal shock wave lithotripsy. 11 Similar results were observed in our study with significant decrease in ambulation time.…”

Section: Parametermentioning

confidence: 96%

Evaluation of the Effect of Sufentanil and Lignocaine Combination in Patients Undergoing Perianal Surgeries Under Spinal Anaesthesia

Madhala

Sridhar

Shaik³

et al. 2016

jemds

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CONTEXTSpinal anaesthesia with hyperbaric lignocaine has the limitation of relatively shorter duration of action, which means that early analgesic intervention is needed in the postoperative period. Intrathecal opioid administration has a promising role in fulfilling this objective. Sufentanil, the congener of fentanyl is 1000 more times potent than morphine is a newer addition to the armoury of modern day anaesthesiologists. AIMSTo compare the efficacy of sufentanil and lignocaine combination with lignocaine alone to reduce postoperative pain in patients undergoing perianal under spinal anaesthesia. SETTINGS AND DESIGNA prospective randomized single blinded study conducted after obtaining written informed consent, 100 patients aged above 18 years belonging to ASA Grade I and II scheduled to undergo perianal surgeries under spinal anaesthesia were enrolled in the study. METHODS AND MATERIALThe study population was divided into two groups of 50 each to receive the following treatments: 5% hyperbaric lignocaine 50 mg and 5% hyperbaric lignocaine 50 mg with sufentanil 10 µg. All the drugs were administered intrathecally. All the patients were explained about the Visual Analog Scale (VAS) and standardized perioperative and anaesthetic procedures were followed. STATISTICAL ANALYSISAll data analysis was completed using SPSS software. Data were expressed as mean±SD. Quantitative data was analysed using unpaired 't' test. Side effects were compared by Chi-square test. P <0.05 was considered as statistically significant. RESULTSThere was no variation with regard to the onset of sensory and motor blockade between the two groups. Significant increase in duration of complete and effective analgesia was observed in sufentanil group and the time for first dose of analgesic postoperatively was also significantly delayed. Pruritus was the most common side effect noted in sufentanil group. CONCLUSIONSufentanil potentiates lignocaine anaesthesia by increasing the duration and quality of analgesia and also decreases the ambulation time with minimal side effects.

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Drug therapy for preventing post-dural puncture headache

Ona

Tůma

García

et al. 2013

Cochrane Database of Systematic Reviews

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L’administration intrathécale de lidocaïne et de sufentanil diminue le temps de récupération après une opération du rectum en chirurgie ambulatoire

Cited by 15 publications

References 28 publications

L’administration prophylactique d’ondansétron ne réduit pas l’incidence de prurit induit par le sufentanil intrathécal

L’administration prophylactique d’ondansétron ne réduit pas l’incidence de prurit induit par le sufentanil intrathécal

Evaluation of the Effect of Sufentanil and Lignocaine Combination in Patients Undergoing Perianal Surgeries Under Spinal Anaesthesia

Drug therapy for preventing post-dural puncture headache

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