L:A ratio, Insulin resistance and metabolic risk in women with polycystic ovarian syndrome

Gupta, Vishal; Mishra, Supriya; Mishra, Sameeksha

doi:10.1016/j.dsx.2017.05.001

Cited by 12 publications

(24 citation statements)

References 24 publications

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“…Reiterating the role of adiponectin in PCOS pathogenesis, animal studies showed that adiponectin treatment reduced androgen synthesis in DHEA-treated PCOS mice in an in vitro study29. In another case-control study, plasma leptin:adiponectin ratio (L:A ratio) seemed to be positively associated with markers of metabolic syndrome and IR, thus reconfirming the lower adiponectin levels to be a potential biomarker of metabolic risk and IR in PCOS women30.…”

Section: Studies On Pcos Pathogenesis From Indiamentioning

confidence: 93%

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

et al. 2019

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting women of reproductive age. Clinical manifestations are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction. This review provides information on the problem of PCOS in India, its pathophysiology, genetics and an overview of current management options to instigate further research in this field. Prevalence of PCOS in India ranges from 3.7 to 22.5 per cent depending on the population studied and the criteria used for diagnosis. Abnormalities in leptin-adiponectin (adipocyte biology), oxidative stress and autoimmunity are among the mechanisms studied regarding pathogenesis of PCOS. Many candidate gene studies have shown associations with PCOS in various studies. Studies have consistently demonstrated the relationship between the well-known manifestation of hyperandrogenism among Indian PCOS women and the metabolic morbidities including insulin resistance, glucose intolerance and cardiovascular risk. Management of individual components of PCOS can be achieved by medications or surgical methods, though further clarification regarding pathogenesis of PCOS is needed to sharpen our therapeutic armamentarium.

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Section: Studies On Pcos Pathogenesis From Indiamentioning

confidence: 93%

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

et al. 2019

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“…This effect may be involved in the high FFA levels and adipocytokines (127). 4) Due to its involvement in leptin and adiponectin signaling, the reduction of adiponectin is significantly related to IR (119,128,129), which can enhance insulin sensitivity by increasing fatty acid oxidation and inhibiting liver glucose production (82). High leptin levels are closely related to IR (80,129).…”

Section: The Possible Mechanism Of Ir/ Hyperinsulinemia Caused By Vpamentioning

confidence: 99%

“…4) Due to its involvement in leptin and adiponectin signaling, the reduction of adiponectin is significantly related to IR (119,128,129), which can enhance insulin sensitivity by increasing fatty acid oxidation and inhibiting liver glucose production (82). High leptin levels are closely related to IR (80,129). 5) Some researchers believe that VPA will injure the liver and affect the metabolism of insulin in the liver, which can bring about an increase in insulin concentrations (81,130).…”

Section: The Possible Mechanism Of Ir/ Hyperinsulinemia Caused By Vpamentioning

confidence: 99%

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Zhang

Wei

et al. 2021

Front. Endocrinol.

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Epilepsy is a common chronic neurological disease that manifests as recurrent seizures. The incidence and prevalence of epilepsy in women are slightly lower than those in men. Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%–13% in the female population and sometimes as high as 26% in female epilepsy patients. The rate of PCOS increased markedly in female patients who chose valproate (VPA), to 1.95 times higher than that of other drugs. In addition, patients receiving other anti-seizure medications (ASMs), such as lamotrigine (LTG), oxcarbazepine (OXC), and carbamazepine (CBZ), also have reproductive endocrine abnormalities. Some scholars believe that the increase in incidence is related not only to epilepsy itself but also to ASMs. Epileptiform discharges can affect the activity of the pulse generator and then interfere with the reproductive endocrine system by breaking the balance of the hypothalamic–pituitary–ovarian (HPO) axis. ASMs may also cause PCOS-like disorders of the reproductive endocrine system through the HPO axis. Moreover, other factors such as hormone metabolism and related signalling pathways also play a role in it.

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“…Tokmak et al, reported similar results as regard waist circumference and W/H ratio in PCOS women [16] . Gupta and Mishra Role Of Insulin Like Growth Factor … 4010 also found significant high value of W/H ratio in PCOS [17] .…”

Section: Discussionmentioning

confidence: 99%

Role Of Insulin Like Growth Factor in Polycystic Ovary Syndrome

El-Hassanin

Shemais²,

and³

2018

The Egyptian Journal of Hospital Medicine

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Objectives:The polycystic ovary syndrome (PCOS) is conventionally defined as a combination of hyperandrogenism and anovulation with polycystic ovaries. Insulin-like growth factor I (IGF-I) is a 70 aa polypeptide hormone with endocrine, paracrine, and autocrine effects. it is now established that the ovary is a site of IGF-I gene expression and reception. However, this huge amount of data could be somehow distractive since different species may produce distinct IGFs (or their relative binding proteins and receptors) at different stages of follicular development. Objective: The aim of this work was to determine the serum level of IGF-I to evaluate its role in PCOS. Subjects and Methods: Twenty-five infertile women with PCOS diagnosed by ultrasound examination and a history of oligomenorrhea, hirsutism and obesity were studied. Serum levels of insulin-like growth factor-1 (IGF-1) and hormonal profile were measured. Fifteen healthy and fertile women with regular menstrual cycles served as a comparison group. Results: The serum levels of IGF-I were significantly elevated in women with PCOS compared with control and there was positive correlation between IGF-I from one side and each of BMI, W/H ratio, LH, LH/FSH ratio, TSN, T/SHBG ratio, right and left ovarian volumes. On the other side, IGF-I was inversely correlated with SHBG, right and left uterine artery PI and RI. Conclusion: The significant finding of this study is that PCOS patients have increased circulating IGF-I levels than healthy controls and it can be used as a biochemical marker for PCOS.

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L:A ratio, Insulin resistance and metabolic risk in women with polycystic ovarian syndrome

Cited by 12 publications

References 24 publications

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Role Of Insulin Like Growth Factor in Polycystic Ovary Syndrome

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