L-5-Oxo-2-pyrrolidinecarboxamides from phenethylamines

Walter, L. A.; Gyurik, Robert J.; Chang, Wei; Barnett, Allen

doi:10.1021/jm00264a045

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“…The data considered in this review clearly demonstrate the high synthetic potential of α-haloketones. Many biologically active heterocyclic compounds have been obtained based on these reagents [62,114,122,126,131,458,508,618,626,[724][725][726][727][728][729][730][731]. This suggests that α-haloketones can be particularly promising synthons in combinatorial synthesis of functionalized carbo-and heterocyclic compounds used in the design of novel highly effective pharmaceuticals with a broad spectrum of bioresponses.…”

Section: Discussionmentioning

confidence: 99%