l -5-Hydroxytryptophan treatment of sleep terrors in children

Bruni, Oliviero; Ferri, Raffaele; Miano, Silvia; Verrillo, Elisabetta

doi:10.1007/s00431-004-1444-7

Cited by 94 publications

(39 citation statements)

References 25 publications

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“…It is well known that the absolute amount and duration of the so-called slow-wave sleep, characterized by monomorphic waves of high voltage in the delta range, as well as the number of awakenings at this stage of sleep, are increased in children and adults with STs. This explains the behavioral changes observed in individuals and the development of research that led to the use of L-5-hydroxytryptophan (L-5-HTP), a precursor of serotonin, as a treatment for this condition 20 .…”

Section: Discussionmentioning

confidence: 99%

Sleep terrors antecedent is common in adolescents with migraine

Fialho

Pinho

Lin

et al. 2013

Arq. Neuro-Psiquiatr.

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Migraine headache is the most common neurological complaint in adolescents 1 . It causes a significant number of missed school days 2 and is associated with several comorbidities, such as sleep disorders, anxiety and depression 3 .Sleep terrors (STs) are considered a parasomnia that are characterized by a sudden arousal from slow-wave sleep with a piercing scream or cry accompanied by autonomic and behavioral manifestations of intense fear 4 . The prevalence is approximately 3% in children and less than 1% in adults 4,5 .Typically, STs are observed in children between the ages of 4 and 12 years and, as in sleepwalking, tend to resolve spontaneously during adolescence 4 . On average, this disorder lasts 3.9 years, but it has a tendency to continue for a longer time period in children with a family history of STs 6 .The correlation between parasomnias and migraines has been described in previous studies, and a common pathophysiologic mechanism that involves the serotonergic system has been suggested 7-9 . ABSTRACTMigraines and sleep terrors (STs) are highly prevalent disorders with striking similarities. The aim of this study was to evaluate the effect of the antecedent of STs by comparing adolescents suffering from migraines with healthy controls in a large consecutive series. Methods: All patients were subjected to a detailed headache questionnaire and were instructed to keep a headache diary during a two-month period. The age range was 10 to 19 years. The diagnosis of STs was defined according to the International Classification of Sleep Disorders. Results: A total of 158 participants were evaluated. Of these participants, 50 suffered from episodic migraines (EMs), 57 had chronic migraines (CMs) and 51 were control subjects (CG). Participants who had a history of STs had significantly more migraines than participants who did not. Conclusions: Migraine is strongly associated with a history of STs in the adolescent population independent of demographics and pain intensity.Key words: night terrors, migraine disorders, headache, adolescent, sleep disorders. Palavras-Chave: terrores noturnos, transtornos de enxaqueca, cefaleia, adolescentes, transtornos do sono. RESUMO

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Section: Discussionmentioning

confidence: 99%

Sleep terrors antecedent is common in adolescents with migraine

Fialho

Pinho

Lin

et al. 2013

Arq. Neuro-Psiquiatr.

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“…SWS slow wave sleep Table 3 Comparison of pediatric parasomnias abnormal excitability of the serotonergic system exists, which, when activated independent of other neurotransmitters involved in arousal, results in motor behaviors but incomplete arousal [21]. This neurotransmitter imbalance could have also implications for treatment with serotonin precursor [6]. Many factors can influence the mechanisms by which parasomnias are determined and expressed clinically.…”

Section: ■ Pathophysiologymentioning

confidence: 98%

Parasomnias in children

Bruni¹,

Finotti

Novelli³

et al. 2008

Somnologie

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The International Classification of Sleep Disorders (ICSD-2) defines parasomnias as "undesirable physical events or experiences that occur during entry into sleep, within sleep, or during arousal from sleep." Parasomnias in childhood are common, more often benign, self-limited and typically resolving in adolescence. However, for the diagnosis it is often difficult to distinguish between other epileptic and/or non-epileptic events during sleep. Polysomnography is not always sufficient for the diagnosis and video polysomnography may be indicated to assist in the definition of parasomnias or other sleep disruption thought to be seizure related or in a presumed parasomnia, especially when it is not possible for the clinician to identify the etiology of the motor activity in sleep. The correct recognition of parasomnias is important to avoid misdiagnosis and to choose the appropriate treatment, when needed. We review here the main form of childhood parasomnias divided into three groups: 1) disorders of arousal (from NREM sleep); 2) parasomnias usually associated with REM sleep; 3) other parasomnias. Further studies are needed to elucidate the genetics, the pathophysiology and the triggering factors and also to clarify the relationship between NREM sleep structure and the occurrence of the episodes. © 2008 Steinkopff-Verlag

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“…Therefore the amount of food eaten and manipulation of dietary intake may affect sleepiness as well as sleep onset latency. There has been fragmented evidence about different nutrients influencing sleep and the effect of essential fatty acids and essential amino acid especially the tryptophan [26]. The timing of meals is also known to influence sleep.…”

Section: Glycemic Indexmentioning

confidence: 99%

Nutritional Modulators of Sleep Disorders

Sarrafi-Zadeh¹

2012

TONUTRAJ

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Abstract:Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to be common consequences of shift work. These rhythms appear to have independent influence on the function of the endocrine system, circadian brain function and gastrointestinal tract. Insufficient sleep and its poor quality due to shift work interfere with beta cells, leptin and ghrelin functioning, resulting in factors for the development and exacerbation of insulin resistance. Human studies found that insufficient sleep alters the levels of leptin and ghrelin, two hormones involved in the regulation of appetite and body fat. Leptin, released by fat cells, signals the brain to feel satiety. Ghrelin, produced in the stomach, signals hunger. Investigations reported that temporarily sleep-deprived individuals experienced hormonal changes along with greater cravings for sweet and fatty foods. A further reason for their cravings is related to the stress hormone cortisol, which can rise with sleep deprivation and contribute to hunger. In addition to altered hormone levels, people who stay awake longer have more opportunity to eat, and late-night eating often includes high-caloric foods. Weight gain is only one of the many side effects of insufficient sleep, but it can lead to long-term health problems, including diabetes. Although more sleep will not automatically result in weight loss, sufficient sleep and a regular sleep schedule are critical in controlling appetite and promoting a healthy eating pattern. Research on sleep and appetite reveals a consistent link between a lower amount of sleep and a higher body mass index (BMI), a ratio of weight-to-height that indicates overweight. Studies showed those who slept less than eight hours a night were more likely to be overweight. Methods: Internet search and discussion with colleagues.Results: Recent research indicates that disruption of sleep can influence food intake and food and nutrients can influence sleep. There is evidence that high protein and carbohydrates meals can influence moods, attention and concentration among normal adult subjects with respect to age, gender and meal time. Women reported greater sleepiness after two hours of carbohydrate meal as opposed to a protein meal. On the other hand men reported greater calmness after a carbohydrate as opposed to a protein meal. Age of subjects may also influence the response to meals. After a carbohydrate or protein rich breakfast, persons older than 40 years felt more tense and less calm with a protein-rich than carbohydraterich meal. In general older subjects preferred carbohydrate than protein meals. Carbohydrate meals are also reported to impair objective performance; carbohydrate rich foods either in breakfast or lunch have exhibited negative influence on neural response such as impaired objective performance and poor sustained attention. A meal consumed close to bedtime is associated with sleep disturbances. Further, solid foods as well as large meals may cause more sleepiness than liquid foods. Studies...

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l -5-Hydroxytryptophan treatment of sleep terrors in children

Cited by 94 publications

References 25 publications

Sleep terrors antecedent is common in adolescents with migraine

Sleep terrors antecedent is common in adolescents with migraine

Parasomnias in children

Nutritional Modulators of Sleep Disorders

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