L‐4‐thiazolylalanine (Protinol), a novel non‐proteinogenic amino acid, demonstrates epidermal and dermal efficacy with clinically observable benefits
Gloria Portocarrero Huang,
Jolanta Idkowiak‐Baldys,
Frank Liebel
et al.
Abstract:ObjectiveFacial skin undergoes major structural and functional changes as a result of intrinsic and extrinsic factors. The goal of the current work is to demonstrate L‐4‐thiazolylalaine (L4, Protinol), a non‐proteinogenic amino acid shown to stimulate production of dermal proteins by fibroblasts, is an alternative efficacious topical ingredient for visible signs of aging.MethodsIn vitro studies using 3D human skin tissue models were performed to show changes in protein and gene expression of key dermal markers… Show more
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