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Nuhn, P.; Breisig, Th.; Taubert, D.; Scherer, D.; Burg, S.; Hebestreit, C.; Graemer, M.; Metzler, M.; Hardes, H.-D.

doi:10.1007/978-3-663-13305-6_12

Cited by 1 publication

(1 citation statement)

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“…[68] It seems that the carriers can act there as a reservoir that prevents cellular siRNA degradation but allows slow, controlled diffusion of the oligonucleotides into the cytoplasm, followed by robust gene knockdown. [69,70] Based on these findings, further developments focused on smaller carrier systems with a size range of 25-40 nm in diameter. For all these studies, nondegradable carriers cross-linked by spermine were used.…”

Section: Knockdown Potential Of Sirna-loaded Cationic Nanohydrogel Pamentioning

confidence: 99%

Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery

Leber

Nuhn

Zentel

2017

Macromolecular Bioscience

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Short pharmaceutical active oligonucleotides such as small interfering RNA (siRNA) or cytidine‐phosphate‐guanosine (CpG) are considered as powerful therapeutic alternatives, especially to medicate hard‐to‐treat diseases (e.g., liver fibrosis or cancer). Unfortunately, these molecules are equipped with poor pharmacokinetic properties that prevent them from translation. Well‐defined nanosized carriers can provide opportunities to optimize their delivery and guide them to their site of action. Among several concepts, this Feature Article focuses on cationic nanohydrogel particles as a universal delivery system for small anionic molecules including siRNA and CpG. Cationic nanohydrogels are derived from preaggregated precursor block copolymers, which are further cross‐linked to obtain well‐defined nanoparticles of tunable sizes and with (degradable) cationic cores. Novel opportunities for oligonucleotide delivery in vitro and in vivo with respect to liver fibrosis therapies will be highlighted as well as perspectives toward modulating the immune system. In general, the approach of covalently stabilized cationic carrier systems can contribute to find advanced oligonucleotide therapeutics.

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Section: Knockdown Potential Of Sirna-loaded Cationic Nanohydrogel Pamentioning

confidence: 99%