Kyste trichilemmal proliférant malin du scalp : une nouvelle observation

Proliferating Trichilemmal Cyst of the Scalp: 9 Cases and Literature Review

“…Presence of zones of necrosis with a strong mitotic activity and marked cytonuclear atypies could be providers of malignancy. However, for most authors, only clear infiltration of the stroma confirms this malignancy [2,12]. Benign PTC would strongly express CK10 and involucrine while in malignant form there would be a high number of cells expressing nuclear proliferation cell antigen and CK16 with loss of CD34 expression [2].…”

“…Histological findings could be confusing with squamous cell carcinoma (SCC); main clinical and histological differential diagnosis; especially of malignant PTC. However, absence of precancerous epidermal lesion such as actinic keratosis and absence of expression of monoclonal antibodies AE13 and AE14 would help to eliminate an SCC [2].…”

“…A wide excision with 1cm of lateral margin and deeply arriving at the periosteum is sufficient in benign cases or low grade of malignancy. This margin should be wider if tumor is predictive of a high risk of metastasis [2]. In some cases, radiotherapy and / or adjuvant chemotherapy based on Fluorouracil and Cisplatin are indicated with discussed efficacy [2,14].…”

“…This margin should be wider if tumor is predictive of a high risk of metastasis [2]. In some cases, radiotherapy and / or adjuvant chemotherapy based on Fluorouracil and Cisplatin are indicated with discussed efficacy [2,14]. Indeed, of the 39 cases of malignant PTC reported by Garg, et al 11 received radiotherapy and / or chemotherapy, 6 of them died after an average of 43 months [15].…”

“…This is mainly due to the rarity of this condition but also to its slow and benign evolution, considered unattractive. However, malignant cases reported (about 50 in total) [2], suggested a renewed interest in PTC and should initiate serial studies to better understand this affection still enigmatic.…”