Kyphosis and Pulmonary Function in Cystic Fibrosis

Logvinoff, Marie-Martine; Fon, Gerald T.; Taussig, Lynn M.; Pitt, Michael J.

doi:10.1177/000992288402300705

Cited by 13 publications

(9 citation statements)

References 5 publications

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“…A vicious cycle may develop with deteriorating posture, lung function, and overall health and wellbeing. However, the evidence base for this is not robust and the suggestion that the chest deformities may in themselves accelerate the rate of decline in lung function is the subject of on-going debate (2–4, 6, 13). …”

Section: Discussionmentioning

confidence: 99%

“…Though the development of thoracic kyphosis in patients with CF has received relatively little attention, previous work has suggested that increased kyphosis is relatively common in this population (2–4). Parasa and Maffulli (5), in their review of musculoskeletal problems in CF, reported that up to 62% of patients had excessive thoracic kyphosis.…”

Section: Introductionmentioning

confidence: 99%

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Thoracic Kyphosis is Now Uncommon Amongst Children and Adolescents with Cystic Fibrosis

et al. 2014

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Historically, thoracic kyphosis has been reported to be common amongst patients with cystic fibrosis (CF). The mechanisms leading to the development of this abnormality of the chest wall are not fully understood. In order to explore the prevalence of the condition amongst children with CF in the early twenty-first century and to explore factors that might be contributing to its development, a retrospective cross sectional study was undertaken in a regional CF unit. Data were obtained from 74 children with CF aged 8–16 years attending for their annual review. Thoracic kyphosis was measured from lateral chest X-ray using an alternative Cobb method. Lung function, disease severity, and nutritional status were also recorded. Correlations between measures were explored using a multiple linear regression model. The range of Cobb angles measured was 5.4–44.3° with thoracic kyphosis identified in only two subjects. There was no correlation between age and thoracic kyphosis, however, there was a significant correlation between lung function and thoracic kyphosis (p = 0.004). Regression coefficient (b) was −0.26 (95% CI: −0.44, −0.08). The prevalence of thoracic kyphosis is significantly less amongst children with CF than previously reported. This appears likely to be associated with the overall improvements in pulmonary status. Studies of older populations may bring further understanding of increasing thoracic kyphosis in people with CF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thoracic Kyphosis is Now Uncommon Amongst Children and Adolescents with Cystic Fibrosis

et al. 2014

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“…Essa relação entre a postura e a mecânica respiratória tem sido foco de discussão de vários autores 2,4,[16][17][18][19][20] . Segundo eles, o aprisionamento de ar é causado pelo processo inflamatório recorrente, hipersecreção brônquica e diminuição do Tabela 4 -Distribuição de frequências e odds ratio bruta em relação às variáveis espirométricas (capacidade vital forçada e volume expiratório forçado no primeiro segundo) e a distância percorrida no teste de caminhada de 6 minutos % = frequência relativa; CVF = capacidade vital forçada; DP no TC 6 = distância percorrida no teste de caminhada de 6 minutos; IC95% = intervalo de confiança de 95%; n = frequência absoluta; OR = odds ratio; VEF 1 = volume expiratório forçado no primeiro segundo.…”

Section: Discussionunclassified

“…Diante desse processo fisiopatológico e sua íntima ligação com a caixa torácica, a alteração postural mais comumente vista na FC é o aumento da cifose torácica 4,[17][18][19][20][21] . Essa alteração foi evidenciada na presente pesquisa, sendo que uma prevalência semelhante à encontrada (62%) também foi observada no trabalho de Parasa & Maffulli 18 .…”

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Influence of thoracic spine postural disorders on cardiorespiratory parameters in children and adolescents with cystic fibrosis

Okuro¹,

Côrrea²,

Conti³

et al. 2012

J Pediatr (Rio J)

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Objectives: To assess the impact of increased thoracic kyphosis on pulmonary function and functional capacity in children and adolescents with cystic fibrosis (CF) and to verify the influence of disease severity, age and nutritional status on this deformity.Method: This was a cross-sectional, analytical study conducted at a university hospital. It included CF patients with confirmed diagnosis and without pulmonary exacerbation. The sample was submitted to postural assessment, spirometry (FEV 1 , FVC and FEV 1 /FVC) and 6-minute walk test distance (6-MWT distance). Data were analyzed using the Mann Whitney test, Spearman correlation and logistic regression.Results: Forty-two patients were enrolled, 61.9% presented increase of thoracic kyphosis. There was no difference in values of FEV 1 , FVC, FEV 1 /FVC and 6-MWT distance between the groups with or without thoracic kyphosis (p = 0.407; p = 0.756; p = 0.415; p = 0.294). In the group without alteration, patients with more disease severity had a mean FEV 1 of 74.1±21.9% and FVC of 79.8±18.7% while in those of lesser severity higher values were found (95.6±12.2% and 97.6±13.2%, respectively) (p = 0.027 and p = 0.027). The presence of kyphosis was correlated with age (p = 0.048) but not with severity (p = 0.151) and body mass index (p = 0.088). Conclusions:There was a high prevalence of increased thoracic kyphosis in children and adolescents with CF. The deformity did not affect pulmonary function and functional capacity and there was no relationship with disease severity. Regardless of posture, worsening of disease severity determined worsening of pulmonary function.J Pediatr (Rio J). 2012;88(4):310-6: Posture, cystic fibrosis, pulmonary function. ResumoObjetivos: Avaliar a repercussão do aumento da cifose torácica na função pulmonar e na capacidade funcional de crianças e adolescentes com fibrose cística e verificar a influência da gravidade da doença, idade e aspectos nutricionais sobre essa deformidade.Método: Estudo analítico de corte transversal, realizado em um hospital universitário. Incluiu fibrocísticos com diagnóstico confirmado e fora de exacerbação pulmonar. A amostra foi submetida à avaliação postural, registro de parâmetros espirométricos -volume expiratório forçado no primeiro segundo (VEF 1 ), capacidade vital forçada (CVF) e VEF 1 /CVF -e da distância percorrida pelo teste de caminhada de 6 minutos. Para análise dos dados, utilizou-se teste de Mann-Whitney, correlação de Spearman e regressão logística, considerando-se nível de significância de 5%. Resultados:No total, 42 pacientes foram incluídos, e 61,9% apresentaram aumento da cifose torácica. Não houve diferença nos valores de VEF 1 , CVF, VEF 1 /CVF e distância percorrida pelo teste de caminhada de 6 minutos entre os grupos com e sem cifose torácica (p = 0,407; p = 0,756; p = 0,415; p = 0,294). No grupo sem alteração postural, fibrocísticos mais graves apresentaram média de VEF 1 de 74,1±21,9% e CVF de 79,8±18,7%, enquanto naqueles de menor gravidade foram verificados valores superiores...

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Transplantation for Cystic Fibrosis: Effect on the Skeleton

Aris

Ontjes

2005

Bone Disease of Organ Transplantation

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Kyphosis and Pulmonary Function in Cystic Fibrosis

Cited by 13 publications

References 5 publications

Thoracic Kyphosis is Now Uncommon Amongst Children and Adolescents with Cystic Fibrosis

Thoracic Kyphosis is Now Uncommon Amongst Children and Adolescents with Cystic Fibrosis

Influence of thoracic spine postural disorders on cardiorespiratory parameters in children and adolescents with cystic fibrosis

Transplantation for Cystic Fibrosis: Effect on the Skeleton

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