Kyoto classification in patients who developed multiple gastric carcinomas after <i>Helicobacter pylori</i> eradication

Sakitani, Kosuke; Nishizawa, Toshihiro; Toyoshima, Akira; Yoshida, Shuntaro; Matsuno, Tatsuya; Yamada, Toshimoto; Irokawa, M.; Takahashi, Yoshiyuki; Nakai, Yousuke; Toyoshima, Osamu; Koike, Kazuhiko

doi:10.4253/wjge.v12.i9.276

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…4), to establish a global standard for gastritis classi cation. The e cacy of Kyoto classi cation of gastritis to GC risk prediction have been proven by Sugimoto, Shichijo, Sakitani and Fujimoto et al (22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of nomogram based on Kyoto classification of gastritis to diagnosis of gastric cancer

Lin

Zhou

et al. 2022

Scandinavian Journal of Gastroenterology

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Background and Aim. It is of importance to predict the risk of gastric cancer (GC) for endoscopists because early detection of GC determines the determines the selection of best treatment strategy and the prognosis of patients. The aim of the study was to evaluate the utility of a predictive nomogram based on Kyoto classi cation of gastritis for GC.Methods. It was a retrospective study that included 2639 patients who received esophagogastroduodenoscopy and serum pepsinogen (PG) assay from January 2020 to November 2020 at the Endoscopy Center of the Department of Gastroenterology, Wenzhou Central Hospital. Routine biopsy was conducted to determine the benign and malignant lesions pathologically. All cases were randomly divided into the training set (70%) and the validation set (30%) by using bootstrap method. A nomogram was formulated according to multivariate analysis of training set. The predictive accuracy and discriminative ability of the nomogram were assessed by concordance index (C-index), area under the curve (AUC) of receiver operating characteristic curve (ROC) as well as calibration curve and were validated by validation set.Results. Multivariate analysis indicated that age, sex, PG I/II ratio and Kyoto classi cation scores were independent predictive variables for GC. The C-index of the nomogram of the training set was 0.79 (95% CI: 0.74 to 0.84) and the AUC of ROC is 0.79. The calibration curve of the nomogram demonstrated an optimal agreement between predicted probability and observed probability of the risk of GC. In the validation set, the C-index was 0.86 (95% CI: 0.79 to 0.94) with a calibration curve of better concurrence.Conclusion. The nomogram formulated was proven to be of high predictive value for GC.

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Section: Discussionmentioning

confidence: 99%

Predictive value of nomogram based on Kyoto classification of gastritis to diagnosis of gastric cancer

Lin

Zhou

et al. 2022

Scandinavian Journal of Gastroenterology

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“…In the Kyoto Classification of Gastritis, atrophy, intestinal metaplasia, diffuse redness, and nodularity are risk factors for gastric cancer [ 22 , 24 , 25 , 26 , 27 , 28 ]. Enlarged fold has also been weakly associated with undifferentiated gastric carcinoma [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Helicobacter pylori-Infected Gastritis in Okinawa and Tokyo Based on the Kyoto Classification of Gastritis

Oki

Takeda

Hojo

et al. 2022

JCM

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The incidence of gastric cancer in Okinawa Prefecture is the lowest in Japan, which is attributed to differences in strains of Helicobacter pylori in Okinawa and other prefectures in Japan. Our aim was to compare the endoscopic findings of H. pylori-infected gastric mucosa in Okinawa and Tokyo. Patients who underwent upper gastrointestinal endoscopy (UGI) at Northern Okinawa Medical Center (Okinawa group) and Juntendo University Hospital (Tokyo group) from April 2019 to March 2020 were included. Patients diagnosed with H. pylori-infected gastric mucosa were retrospectively compared between the Okinawa and Tokyo groups according to the Kyoto Classification of Gastritis. The numbers of subjects (Okinawa/Tokyo) were 435/352, male/female ratio was 247:188/181:171, and age was 53.3 ± 14.7/64.6 ± 14.3 (mean ± standard deviation) years. Regarding the Kyoto Classification of Gastritis, the prevalence (Okinawa/Tokyo) of the closed type of atrophic gastritis was 73%/37% (p < 0.001), diffuse redness 80%/84% (p = 0.145), mucosal swelling 46%/46% (p = 0.991), enlarged fold 26%/32% (p = 0.048), spotty redness 77%/68% (p = 0.002), sticky mucus 17%/36% (p < 0.001), and intestinal metaplasia 32%/42% (p < 0.001). Age analysis also revealed that closed-type atrophy and spotty redness were more frequent in the Okinawa group than in the Tokyo group. There may be regional differences in endoscopic findings of H. pylori-infected gastric mucosa between Okinawa and Tokyo.

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“…Upper GI inflammatory diseases 67 gastric cancer, 79,80 and score decreased following H. pylori eradication. 81 As shown in the Table 1, severity of atrophy, intestinal metaplasia that is a result of advanced atrophy, male sex, and having map-like redness and diffuse redness indicate the risk of gastric cancer.…”

Section: Evaluation Of Gastric Cancer Riskmentioning

confidence: 94%

“…81 As shown in the Table 1, severity of atrophy, intestinal metaplasia that is a result of advanced atrophy, male sex, and having map-like redness and diffuse redness indicate the risk of gastric cancer. 79,80,82,83,84…”

Section: Evaluation Of Gastric Cancer Riskmentioning

confidence: 99%

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

Nagahara

Shiotani

Iijima

et al. 2021

Digestive Endoscopy

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The Japan Gastroenterological Endoscopy Society held four serial symposia between 2019 and 2020 on the state-of-the-art of issues related to upper GI inflammatory diseases. This review discusses some of the topics addressed in these symposia. The papers regarding nonerosive reflux disease, recent improvements in intraesophageal pH-impedance monitoring and endoscopic diagnosis using image-enhanced endoscopy have been published. Many publications have addressed its usefulness in endoscopic treatment of gastroesophageal reflux disease such as anti-reflux mucosectomy. In the management of eosinophilic esophagitis, since the symptoms are subjective, objective indicators have been sought, and ultrasonography and highresolution manometry may be useful tools for evaluation. The natural course of this condition, especially of asymptomatic cases, is not well clarified. Some newly developed anti-acid or anti-inflammatory medicines are now under investigation. With regard to autoimmune gastritis, because of widespread medical examinations, diagnosis of asymptomatic cases has been increasing. Recently, its endoscopic characteristics have become clear and the natural history of these conditions is being elucidated. The Kyoto Classification of Gastritis has been reported to be useful not only for Helicobacter pylori diagnosis but also for identification of risks of gastric cancer. Its usefulness is now recognized in Asia and Europe.

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Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication

Cited by 8 publications

References 35 publications

Predictive value of nomogram based on Kyoto classification of gastritis to diagnosis of gastric cancer

Predictive value of nomogram based on Kyoto classification of gastritis to diagnosis of gastric cancer

Comparative Study of Helicobacter pylori-Infected Gastritis in Okinawa and Tokyo Based on the Kyoto Classification of Gastritis

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

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