Kynurenine and Pteridines in Changes of Membrane Fluidity

Rudzite, Vera; Jurika, Edite; Fuchs, Dietmar; Baier‐Bitterlich, Gabriele; Wächter, Helmut

doi:10.1007/978-1-4613-0381-7_39

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…The results obtained in this study after addition of L-kynurenine to incubation medium for phospholipid biosynthesis in vitro agree with results obtained in our previous investigations (3,4): the incorporation of palmitic, oleic and linolenic acid increased, while incorporation of linoleic and arachidonic acid decreased in phospholipids. These deviations were followed by an increase of cholesterol and a decrease of phospholipid content in samples containing L-kynurenine .…”

Section: Discussionsupporting

confidence: 92%

“…The results of our previous in- § Correspondence: Dr. Dietmar Fuchs, Institute of Medical Chemistry and Biochemistry, University of Innsbmck, Fritz Prcgl Strasse 3, A-6020 Innsbmck, Austria vestigations have shown that L-kynurenine increases palmitic, oleic and linolenic acid incorporation into phospholipids and decreases the incorporation of linoleic and arachidonic acid. The cholesterol content increases and phospholipid content decreases in samples containing L-kynurenine ( 3,4). It is known from the literature that such changes in lipid metabolism are followed by decrease of membrane fluidity (5,6), calcium accumulation in cells and cholesterol precipitation (7-Pteridines/ Vol.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Kynurenine and Its Metabolites on Lipid Metabolism

Rudzite¹,

Jurika²,

Jirgensons³

et al. 1997

Pteridines

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SummaryIncorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of L-kynurenine (4 nmoljg wet weight) to incubation medium induced an increase of palmitic, oleic and linolenic acid and decrease of linoleic and arachidonic acid incorporation into phospholipids . These changes of fatty acid incorporation into phospholipids were followed by increase of cholesterol and decrease of phospholipids content in samples. The addition of 3-hydroxykynurenine (1.8 and 4 nmoljg wet weight), 3-hydroxyanthranilic acid (2.2 and 4 nmoljg wet weight) ,1n..:l quinolinic acid (2.4 and 4 nmoljg wet weight) to incubation medium for phospholipid biosynthesis ill vitro induced a decrease of stearic, palrnitic and linoleic acid and an increase of oleic and especially arachidonic acid incorporation into phospholipids. These changes were accompanied by a decrease of cholesterol content in samples . The influence of kynurenine on fatty acid incorporation into phospholipids was similar to that of neopterin observed earlier. The other tryptophan degradation products behaved similar to the reduced pteridine derivatives. Our results allow to suggest that L-kynurenine decreases, while 3-hydroxykynurenine, 3-hydroxyanthranilic acid and quinolinic acid increase membrane fluidity in the studied concentrations .

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Influence of Kynurenine and Its Metabolites on Lipid Metabolism

Rudzite¹,

Jurika²,

Jirgensons³

et al. 1997

Pteridines

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“…Although the effect of L-KYN metabolites has been intensively studied in their receptor action in the CNS and also in the periphery, no data are available about their function within the cell. Recently it has been shown that in the rat liver homogenate, L-KYN significantly altered the membrane composition [14]. These data would suggest that changes in L-KYN metabolism may influence the function of subcellular organelles, e.g.…”

Section: L-kynurenine (L-kyn) Is a Major Intermediate In The Oxidativmentioning

confidence: 97%

Kynurenic Acid Influences the Respiratory Parameters of Rat Heart Mitochondria

et al. 2001

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In the present study the effect of L-kynurenine, kynurenic acid and quinolinic acid on the heart mitochondrial function were investigated. Mitochondria were incubated with saturating concentrations of respiratory substrates glutamate/malate (5 mmol/l), succinate (10 mmol/l) or NADH (1 mmol/l), with and without kynurenines. The concentration of kynurenines varied between 1.25 µmol/l and 10 mmol/l. From all investigated kynurenines, only kynurenic acid affected dose-dependently the respiratory parameters of heart mitochondria. Respiratory control and P/O values were reduced significantly with glutamate/malate and moderately with succinate as substrates in the presence of 125 µmol/l to 10 mmol/l kynurenic acid. A known elevation of L-kynurenine in the blood of patients with ischemic heart disease or essential hypertension may suggest the involvement of L-kynurenine metabolites in the impairment of heart mitochondrial function, for example in cardiomyopathy.

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Kynurenine and Pteridines in Changes of Membrane Fluidity

Cited by 2 publications

References 10 publications

The Influence of Kynurenine and Its Metabolites on Lipid Metabolism

The Influence of Kynurenine and Its Metabolites on Lipid Metabolism

Kynurenic Acid Influences the Respiratory Parameters of Rat Heart Mitochondria

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