Kutane Infektion durch Fusarium oxysporum bei einer Diabetikerin

Nenoff, P.; Bernhardt, Anne; Tintelnot, Kathrin; Kingreen, Volker; Dücker, P.; Cofalka, M.; Schaller, Jörg

doi:10.1007/s00105-014-2774-7

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Fusarium species occur worldwide in nature and cause diseases like fungal keratitis, secondary infections of the skin, eumycetomas and in a setting of neutropenia, systemic mycosis. They can produce mycotoxins [7,8]. On histology, the hyphae of Fusarium solani resemble those of aspergillus.…”

Section: Discussionmentioning

confidence: 99%

Eumycetoma: An unexpected diagnosis in Central Europe

Godde

2023

J Clin Images Med Case Rep

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Section: Discussionmentioning

confidence: 99%

Eumycetoma: An unexpected diagnosis in Central Europe

Godde

2023

J Clin Images Med Case Rep

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Exocellular extract of Fusarium oxysporum, fungus free, is able to permeate and act selectively in skin

Melo

Correia

Svidzinski

et al. 2018

APMIS

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The skin is an important gateway for Fusarium infection in humans. Our hypothesis is that metabolites produced by Fusarium oxysporum should change the barrier structure to permeate the skin. Male Wistar rats received a topical application of a solution (0.05 mg/mL) of Fusarium metabolites. The animals were euthanized 3, 6, 12, 24 h after and the skin was processed for immunostaining by laminin and E-cadherin to investigate whether the Fusarium metabolites can break the barrier of healthy skin. Other techniques were employed: H&E to study the morphology; metalloproteinase-9 (MMP-9), TUNEL, and PCNA immunostaining to evaluate the inflammation, cell death, and proliferation, respectively. There was an inflammatory response mainly centered in the dermis. Qualitatively, the skin of the experimental group showed reduced E-cadherin and laminin immunostaining at 3, 12, and 24 h. Higher intensity staining by TUNEL at 3 h, and PCNA at 6, 12, and 24 h. There was intense MMP-9 activity at 6, 12, and 24 h. None of analyses revealed any changes in the epidermis. It was concluded that the fraction was able to permeate the skin and act selectively in dermis, inducing inflammatory response, increasing MMP-9 immunostaining, inducing apoptosis, and reducing E-cadherin and laminin immunostaining.

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Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Nenoff

Sande

Fahal

et al. 2015

Acad Dermatol Venereol

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103

118

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Mycetoma is a chronic putrid infection of the cutaneous and subcutaneous tissue concerning predominantly the feet, and more rarely other body parts. Mycetoma can be caused by both fungi (eumycetoma) and bacteria (actinomycetoma). Mode of infection is an inoculation of the causative microorganism via small injuries of the skin. The clinical correlate of both forms of mycetoma is tumescence with abscesses, painless nodules, sinuses and discharge. The latter is commonly serous-purulent and contains grains (filamentous granules) which can be expressed for diagnostic purposes. Distinctive for both eumycetoma and actinomycetoma, are the formation of grains. Grains represent microcolonies of the microorganism in vivo in the vital tissue. The most successful treatment option for eumycetomas offers itraconazole in a dosage of 200 mg twice daily. This triazole antifungal is considered as 'gold standard' for eumycetomas. Alternatively, the cheaper ketoconazole was widely used, however, it was currently stopped by the FDA. Actinomycetomas should be treated by the combination of trimethoprim-sulphamethoxazole (co-trimoxazole 80/400 to 160/800 mg per day) and amikacin 15 mg/kg body weight per day. Mycetomas are neglected infections of the poor. They are more than a medical challenge. In rural areas of Africa, Asia and South America mycetomas lead to socio-economic consequences involving the affected patients, their families and the society in general.

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Kutane Infektion durch Fusarium oxysporum bei einer Diabetikerin

Abstract: Cutaneous fusarium infections are rare but emerging opportunistic infections. Histological examination represents the quickest diagnostic method for detection of the fungal infection. An alternative approach represents the species identification based on molecular techniques.

Cited by 4 publications

References 15 publications

Eumycetoma: An unexpected diagnosis in Central Europe

Eumycetoma: An unexpected diagnosis in Central Europe

Exocellular extract of Fusarium oxysporum, fungus free, is able to permeate and act selectively in skin

Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

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