Kupffer cells in well-differentiated tissue of hepatocellular carcinoma.

Tobe, Kazuo; Fujiwara, Ryoji; Yamada, Gotaro; Nagashima, Hideo; Sasaoka, Kazuo; Mimura, Hisashi; Motoi, Makoto

doi:10.2957/kanzo.26.630

Cited by 8 publications

(4 citation statements)

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“…However, several studies have indicated that immunodeficiency virus. 10 With the exception of CD32 on placental blood vessels, 38 these antigens are not found on the the SECs in HCCs frequently anchor Kupffer cell-like macrophages, 17,18 and that SECs in some differentiated HCCs ECs of ordinary vessels. The SECs in the 12 well-differentiated HCCs simultaneously expressed at least 2 antigens rarely possess basement membrane.…”

Section: Laminin Was Found In the Subendothelium Of The Sinusoidsmentioning

confidence: 99%

“…Staining for laminin cells, is generally considered to resemble the capillary endoand PAL-E Ag showed an inverse relationship to the expresthelia, 15,16 but several studies have indicated that the sinusoision of CD4, CD14, and CD32 on HCC SECs and the tumor dal endothelia of early HCC contains Kupffer cell-like macdifferentiation. In conclusion, the phenotypes of the SECs in rophages, 17,18 and shows morphological characteristics early and well-differentiated HCC are thought to be similar intermediate between those of ordinary capillary endothelia to those of the SECs in normal liver. With progressing tumor and the sinusoidal endothelia in normal liver.…”

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confidence: 99%

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Immunohistochemical studies on endothelial cell phenotype in hepatocellular carcinoma

et al. 1997

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and functionally from ordinary endothelia. 2,3 SECs play an To examine the phenotype of the sinusoidal endothelial important role in the receptor-mediated clearance of various cells (SECs) surrounding tumor cells and the process of capilmacromolecules from the blood, including small particulate larization in hepatocellular carcinoma (HCC), 51 primary substances. In chronic hepatitis and cirrhosis, SECs frequently undergo CD4, CD14, and/or CD32 were found on HCC SECs only in transformation into capillary ECs possessing a basement 12 well-differentiated primary HCCs showing a thin trabecumembrane and no fenestrae, i.e., capillarization, 13 and they lar or pseudoglandular tumor cell arrangement. These 12 tulose some of their phenotypic features (including FcR expresmors were smaller than those without CD4-, CD14-, and/or sion) regardless of whether sinusoidal capillarization oc-CD32-positive SECs (P õ .05). Among them, 7, 5, and 11 curs. 8,14 In hepatocellular carcinoma (HCC), the endothelia tumors were negative or only partially positive for laminin, of the sinusoids, i.e., the blood vessels surrounding tumor PAL-E Ag, and FVIIIRAg, respectively. Staining for laminin cells, is generally considered to resemble the capillary endoand PAL-E Ag showed an inverse relationship to the expresthelia, 15,16 but several studies have indicated that the sinusoision of CD4, CD14, and CD32 on HCC SECs and the tumor dal endothelia of early HCC contains Kupffer cell-like macdifferentiation. In conclusion, the phenotypes of the SECs in rophages, 17,18 and shows morphological characteristics early and well-differentiated HCC are thought to be similar intermediate between those of ordinary capillary endothelia to those of the SECs in normal liver. With progressing tumor and the sinusoidal endothelia in normal liver. 19,20 It seems dedifferentiation the HCC SECs lose the phenotypes peculiar that the phenotypes of the SECs in HCC (HCC SECs) graduto liver SECs and acquire the characteristics of capillary ECs, ally changes into that of capillary ECs with tumor progresthough both types of phenotypical change occur indepension. However, the change in the expression of the receptors dently of each other. (HEPATOLOGY 1997;26:407-415.) and adhesion molecules specifically detected on SECs are unclear. This is important for understanding not only the Hepatic sinusoidal endothelial cells (SECs) are unique biological nature of HCC SECs, which are major stromal cells endothelial cells (ECs), which possess fenestrae and no basesupporting HCC cells, but also the pathobiology of sinusoidal ment membrane, and reside together with tissue-fixed macrocapillarization. phages, i.e., Kupffer cells. 1 SECs differ both morphologicallyIn the present study, to analyze the relationship between the phenotypes of SECs and sinusoidal capillarization in

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Section: Laminin Was Found In the Subendothelium Of The Sinusoidsmentioning

confidence: 99%

mentioning

confidence: 99%

Immunohistochemical studies on endothelial cell phenotype in hepatocellular carcinoma

et al. 1997

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“…The absence of perfusion defects on CEUS with Sonazoid images in the post-vascular phase may have been caused by portal vein tumor thrombus in the vicinity of the tumor. The number of Kupffer cells reduces as the biological malignancy of HCC progresses (5)(6)(7). Furthermore, the post-vascular phase of Sonazoid-enhanced US imaging mainly reflects the number and functional role of the Kupffer cells in the liver, indicating that, in the case of hypervascular HCC, defects are present during the post-vascular phase of US (4).…”

Section: Discussionmentioning

confidence: 99%

A case of poorly differentiated hepatocellular carcinoma with intriguing ultrasonography findings

et al. 2012

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A 60-year-old female was referred to the Toho University Omori Medical Center due to ultrasonography findings revealing a notable hepatic mass. The 44×32 mm isoechoic mass had a high-echo band along the margin in the liver. Contrast-enhanced ultrasonography (CEUS) with Sonazoid detected an enhancement pattern extending from the outer periphery to the inside of the mass in the vascular phase and a pattern similar to that of surrounding hepatic tissue in the post-vascular phase. High-flow hepatic hemangioma was suspected due to the hyperechoic rim-like high-echo band, the oval shape and the CEUS findings. However, computed tomography revealed a hypervascular hepatocellular carcinoma (HCC) pattern and the patient underwent surgery. Histopathological findings revealed poorly differentiated HCC. As poorly and moderately differentiated HCC types are conventionally classified as 'hypervascular HCC', few detailed ultrasonography (US) studies of poorly differentiated HCC are available. US characteristics of hypervascular HCC include the presence of a halo (hypoechoic band) around the lesion and reduced signal intensity in the post-vascular phase of CEUS. US in the patient revealed a mass with a hyperechoic band and a signal intensity in the post-vascular phase of CEUS that was almost identical to that of the surrounding liver parenchyma. These findings suggest poorly differentiated HCC and indicate that further research on hypervascular HCC is required.

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“…Increasing evidence suggests that the ability of Sonazoid-enhanced US to detect liver metastases is superior to that of computed tomography [3,13,18]. Qualitative diagnosis, including determination of the degree of differentiation of newly developed, small, well-differentiated hepatocellular carcinomas (HCCs) [5,15,19,20,21,22,23], has been achieved by evaluating the decreased echogenicity associated with a reduced distribution of Kupffer cells [24,25,26]. However, the evaluation of Kupffer images in the postvascular phase has focused only on the inside of the lesion, whereas altered imaging patterns in the area surrounding the lesion have not attracted much attention.…”

Section: Introductionmentioning

confidence: 99%

Hyperenhanced Rim Surrounding Liver Metastatic Tumors in the Postvascular Phase of Sonazoid-Enhanced Ultrasonography: A Histological Indication of the Presence of Kupffer Cells

Tochio¹,

Sugahara²,

Imai

et al. 2015

Oncology

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Aim: A hyperenhanced rim (termed ‘HER') in the postvascular phase is detected in some cases of liver metastasis by Sonazoid-enhanced ultrasonography (US). Here, the association of the HER with histological features was investigated to clarify the cause of this characteristic imaging pattern. Subjects and Methods: A total of 13 hepatic nodules obtained from 11 patients with metastatic liver cancer who underwent Sonazoid-enhanced US followed by surgical resection were analyzed. The distribution density of CD68-positive cells in the tumor rim and the nontumor area was calculated and compared between the HER-positive and HER-negative groups. The relation between the pathological features of the tumor rim and the rate of necrosis within the tumor was also investigated. Results: In the HER-positive group (n = 8), the distribution density of CD68-positive cells was 2.9 ± 0.9, which was significantly higher than that (1.0 ± 0.3) in the HER-negative group (p < 0.05). Inflammatory cell infiltrates, including CD8-positive lymphocytes, were detected in all the HER-positive cases in the area surrounding the tumor, while fibrosis was observed in all the HER-negative cases. The necrotic area within the tumor was significantly larger in the HER-negative group. Conclusion: The HER-positive sign in liver metastases could reflect an increase in Kupffer cells in the tumor rim. The presence of the HER was associated with inflammatory cell infiltrates including CD8-positive lymphocytes surrounding the metastatic liver tumor.

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Kupffer cells in well-differentiated tissue of hepatocellular carcinoma.

Cited by 8 publications

References 0 publications

Immunohistochemical studies on endothelial cell phenotype in hepatocellular carcinoma

Immunohistochemical studies on endothelial cell phenotype in hepatocellular carcinoma

A case of poorly differentiated hepatocellular carcinoma with intriguing ultrasonography findings

Hyperenhanced Rim Surrounding Liver Metastatic Tumors in the Postvascular Phase of Sonazoid-Enhanced Ultrasonography: A Histological Indication of the Presence of Kupffer Cells

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