Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury

Czech, Torrey; Seki, Ekihiro

doi:10.1016/j.jcmgh.2019.10.001

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Protective effects of epigallocatechin‐3‐gallate (EGCG), the polyphenols from green tea, in alleviating alcohol hangover symptoms have also been approved. Czech and Seki ( 2020 ) reported that EGCG may be used as a promising therapy for alcohol‐induced disorders. EGCG supplementation in rats can regulate toll‐like receptors (TLRs) and has been shown to suppress the elevation of intrahepatic TLRs (TLR2, TLR4, and TLR9) in the Kupffer cells by inducing the production of immunomodulatory cytokines such as interleukin‐10 (IL‐10) (Liu et al, 2014 ).…”

Section: Alleviation Of Ethanol‐induced Injuries and Hangover Symptom...mentioning

confidence: 99%

“…The home‐based detoxification of drinkers with hangover symptoms without a need for hospitalization is critical to prevent organ damage or unintended death. Several studies have shown that natural food components and medicinal extracts with antioxidant properties can relieve the severe symptoms of alcohol hangovers (Cui et al, 2014 ; Czech & Seki, 2020 ; Srinivasan et al, 2019 ; Uto‐Kondo et al, 2018 , 2020 ). The underlying detoxification mechanisms of natural food extracts in suppressing hangover symptoms are not well documented.…”

Section: Introductionmentioning

confidence: 99%

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Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Moslemi

Jannat

Mahmoudzadeh

et al. 2023

Food Science & Nutrition

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Alcohol drinking is a popular activity among adolescents in many countries, largely due to its pleasant, relaxing effects. As a major concern, ethanol consumption put the drinkers at risk of nutrients' deficiency due to the disordered eating, anorexia, and malabsorption of nutrients. Moreover, alcohol drinking may lead to the development of hangover symptoms including diarrhea, thirsty, fatigue, and oxidative stress. A broad range of functional food components with antioxidant and/or anti‐inflammatory properties including pectin, aloe vera polysaccharides, chito‐oligosaccharides, and other herbal components have been explored due to their detoxification effects against ethanol. The underlying anti‐hangover mechanisms include reducing the intestinal absorption of ethanol or its metabolites, increasing the activity of ethanol metabolizing enzymes, development of fatty acid β‐oxidation in mitochondria, inhibition of inflammatory response, blocking the target receptors of ethanol in the body, and possession of antioxidant activity under the oxidative stress developed by ethanol consumption. Therefore, the development of bioactive food‐based therapeutic formula can assist clinicians and also drinkers in the alleviation of alcohol side effects.

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Section: Alleviation Of Ethanol‐induced Injuries and Hangover Symptom...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Moslemi

Jannat

Mahmoudzadeh

et al. 2023

Food Science & Nutrition

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“…Hepatic Ischemia/Reperfusion (I/R) injury is a key factor affecting the success of surgery such as lobectomy and liver transplantation, which can increase postoperative mortality [1,2] . Kupffer cells are a special kind of macrophages that are located in the liver sinusoids and account for 80 %-90 % of total body mononuclear macrophages, which are clean guards for the liver, and over activation of Kupffer cells can produce a large number of oxygen free radicals and inflammation related factors, aggravating tissue damage [3][4][5] . Therefore, avoiding the over activation of Kupffer cells is of great importance to clinically reduce hepatic I/R injury.…”

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confidence: 99%

Effects of Propofol on Oxidative Stress Injury and Silent Information Regulator 1/Forkhead Box Protein 1 Pathway of Kupffer Cells

Wen,

Gu,

Zhu

et al. 2023

IJPS

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Wen et al.: Effects of Propofol on Kupffer Cells Induced by Hydrogen PeroxideTo investigate the effect of propofol on oxidative stress injury and silent information regulator 1/forkhead box protein 1 pathway of Kupffer cells induced by hydrogen peroxide. Kupffer cells were cultured in vitro, cell injury model was established by hydrogen peroxide induction, and it was divided into three groups; hydrogen peroxide injury group (300 μmol•l -1 ), propofol low (12.5 μg.ml -1 ), propofol medium (25.0 μg.ml -1 ), and propofol high (50.0 μg•ml -1 ) groups, in addition, Kupffer cells without any treatment were normal control group. Compared with normal control group ((100.00±0.00) %, ( 98.19±2.48), (3.76±0.21) pg/ml, (2.46±0.25) ng/l, (2.47±0.16) pmol/mg, (1.01±0.09), (8.31±0.23), (1.03±0.08), (1.12±0.11), (2.18±0.13)), the Kupffer cell survival rate (56.24±2.12) %, tetramethylrhodamine ethyl ester fluorescence intensity (54.57±2.64), contents of superoxide dismutase (2.51±0.19) pg/ml, catalase (1.23±0.14) ng/l, glutathione peroxidase in cell supernatant (1.31±0.11) pmol/mg, silent information regulator 1 (0.21±0.02), forkhead box protein 1 messenger ribonucleic acid (0.99±0.03) and protein expressions [(0.19±0.02), (0.11±0.01)) decreased significantly in hydrogen peroxide group (p<0.05), and the content of malondialdehyde (4.56±0.37) mol/l in supernatant increased significantly (p<0.05); compared with hydrogen peroxide group, the Kupffer cell survival rate ((64.79±2.49) %, (72.62±2.53) %, (84.91±2.87) %), tetramethylrhodamine ethyl ester fluorescence intensity [(67.28±2.51), (80.65±2.64), (94.19±3.05)), contents of superoxide dismutase ((2.89±0.23) pg/ml, (3.24±0.15) pg/ml, (3.57±0.18) pg/ml), catalase ((1.57±0.18) ng/l, (1.88±0.19) ng/l, (2.23±0.17) ng/l), glutathione peroxidase in cell supernatant ((1.76±0.15) pmol/mg, (2.03±0.16) pmol/mg, (2.39±0.17) pmol/mg), silent information regulator 1 ((0.39±0.03), (0.52±0.04), (0.86±0.05)), forkhead box protein 1 messenger ribonucleic acid ((2.85±0.27), (4.11±0.22), (6.19±0.36)) and protein expressions (silent information regulator 1: (0.48±0.04), (0.71±0.06), (1.01±0.07)), (forkhead box protein 1: (0.45±0.06), (0.64±0.07), (0.87±0.09)) increased significantly in turn of propofol low group, propofol medium group and propofol high group (p<0.05), and the content of malondialdehyde ((4.18±0.35) mol/l, (3.62±0.14) mol/l, (2.87±0.17) mol/l) in supernatant decreased significantly in turn (p<0.05). Propofol can alleviate the oxidative stress injury of Kupffer cells induced by hydrogen peroxide and promote their survival, which may be related to the regulation of silent information regulator 1/forkhead box protein 1 pathway.

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Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress

Yan

Hao

Shi

et al. 2021

International Immunopharmacology

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Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury

Cited by 3 publications

References 5 publications

Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Effects of Propofol on Oxidative Stress Injury and Silent Information Regulator 1/Forkhead Box Protein 1 Pathway of Kupffer Cells

Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress

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