Kundalini Yoga for Post-Treatment Lyme Disease: A Preliminary Randomized Study

Murray, Lilly A; Alexander, Corinne E.; Bennett, Clair; Kuvaldina, Mara; Khalsa, Gurucharan Singh; Fallon, Brian A.

doi:10.3390/healthcare10071314

Cited by 3 publications

(6 citation statements)

References 65 publications

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“…One study had low risk of bias in all assessed items [27]. Two studies had ratings of high risk of bias in several items [28, 29].…”

Section: Resultsmentioning

confidence: 99%

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Dersch,

Torbahn,

Rauer

2024

Euro J of Neurology

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Background and purposeResidual symptoms after treatment of Lyme disease, sometimes called post‐treatment Lyme disease symptoms (PTLDs), are a matter of ongoing controversy. To guide treatment recommendations, a systematic review was performed of the available literature on specific treatment for PTLDs.MethodsA systematic literature search of MEDLINE and CENTRAL was performed. No restrictions on case definitions, study types or specific interventions were applied to enable a comprehensive overview of the available literature. Risk of bias was assessed using the Cochrane risk of bias tools for randomized controlled trials. Certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach. Outcomes of interest were quality of life, fatigue, depression and cognition as well as adverse events.ResultsAfter screening 1274 records, eight eligible randomized controlled trials were included. Heterogeneity was observed regarding inclusion criteria, intervention, length of treatment and outcome measures. For efficacy outcomes, results are presented narratively due to heterogeneity. Eligible studies show no statistically significant difference between antibiotics and placebo regarding quality of life, cognition and depression. Results for fatigue were inconsistent whilst studies with low risk of bias showed no statistically significant difference between antibiotics and placebo. Meta‐analysis of safety outcomes showed statistically significantly more adverse events for antibiotics compared to placebo.ConclusionsAvailable literature on treatment of PTLDs is heterogeneous, but overall shows evidence of no effect of antibiotics regarding quality of life, depression, cognition and fatigue whilst showing more adverse events. Patients with suspected PTLDs should not be treated with antibiotics.

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“…One study had low risk of bias in all assessed items [27]. Two studies had ratings of high risk of bias in several items [28, 29].…”

Section: Resultsmentioning

confidence: 99%

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Dersch,

Torbahn,

Rauer

2024

Euro J of Neurology

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“…Kundalini yoga has also been examined as a potential treatment for PTLDS; yoga has been shown to alleviate fatigue, pain, sleep disturbance, and cognitive impairment [ 56 ]. Additionally, contemplative practices have been theorized to mediate these symptoms due to their effects on the autonomic nervous system and attenuation of the stress response.…”

Section: Reviewmentioning

confidence: 99%

“…In 2022, Murray et al [ 56 ] conducted a preliminary randomized study to determine the adherence to and potential benefit of Kundalini yoga for PTLDS. A total of 29 participants were randomly assigned to either eight weeks of Kundalini yoga in group sessions or a “waitlist” control group.…”

Section: Reviewmentioning

confidence: 99%

“…Still, Kundalini yoga was associated with improvement in two of the secondary outcomes: symptom burden and cognition. The authors concluded that Kundalini yoga is safe and cost-effective and may effectively decrease some of the symptoms associated with PTLDS [ 56 ].…”

Section: Reviewmentioning

confidence: 99%

“…LYMErix is a vaccine for Lyme disease that was developed in the 1990s and was found to reduce infections in vaccinated adults by 80%. However, it was discontinued by the manufacturer due to the low use of the vaccine by the general population [ 56 ]. Because Lyme disease is challenging to diagnose and is debilitating when not treated promptly, prevention is key in protecting both children and adults from the disease.…”

Section: Reviewmentioning

confidence: 99%

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Lyme Disease and Post-treatment Lyme Disease Syndrome: Current and Developing Treatment Options

Talbot¹,

Spillers²,

Luther³

et al. 2023

Cureus

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Lyme disease and its treatment implications have become an ever-increasing area of concern within the United States related to the markedly increased prevalence of infection within the last two decades. The presentation, pathophysiology, and epidemiology of Lyme disease have been well studied, and thus treatments for this disease are widely available. While the treatment of its early and late stages is relatively simple with 10-14 day and four-week courses of doxycycline, respectively, the main problem rests in the understanding of the etiology and pathology of post-treatment Lyme disease syndrome (PTLDS). With the time of symptoms onsetting approximately six months after treatment and potentially lasting indefinitely, this syndrome's effect on patients' quality of life could be devastating. Searching on PubMed, Google Scholar, MEDLINE, and ScienceDirect using keywords including Lyme disease, PTLDS, doxycycline, erythema migrans, azlocillin, and treatment, the authors have tried to make clear the different aspects. The authors have reviewed and discussed clinical studies of Lyme disease and its treatments/potential therapeutics as well as PTLDS and its sparse treatments/potential therapeutics.

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Posttreatment Lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and comparison of pathogenesis

Bai¹,

Richardson²

2023

Chronic Diseases and Translational Medicine

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Lyme disease is the most common vector‐borne illness in the United States and has been causing significant morbidity since its discovery in 1977. It is well‐documented that about 10% of patients properly treated with antibiotics never fully recover, but instead go on to develop a chronic illness dubbed, posttreatment Lyme disease syndrome (PTLDS) characterized by severe fatigue, cognitive slowing, chronic pain, and sleep difficulties. This review includes 18 studies that detail the symptoms of patients with PTLDS and uses qualitative analysis to compare them to myalgic encephalitis/chronic fatigue syndrome (ME/CFS), a strikingly similar syndrome. In the majority of the PTLDS studies, at least four of the six major symptoms of ME/CFS were also noted, including substantial impairment in activity level and fatigue for more than 6 months, post‐exertional malaise, and unrefreshing sleep. In one of the included PTLDS articles, 26 of the 29 ME/CFS symptoms were noted. This study adds to the expanding literature on the post‐active phase of infection syndromes, which suggests that chronic illnesses such as PTLDS and ME/CFS have similar pathogenesis despite different infectious origins.

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Kundalini Yoga for Post-Treatment Lyme Disease: A Preliminary Randomized Study

Cited by 3 publications

References 65 publications

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Lyme Disease and Post-treatment Lyme Disease Syndrome: Current and Developing Treatment Options

Posttreatment Lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and comparison of pathogenesis

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