Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi

Reticulibacter mediterranei gen. nov., sp. nov., within the new family Reticulibacteraceae fam. nov., and Ktedonospora formicarum gen. nov., sp. nov., Ktedonobacter robiniae sp. nov., Dictyobacter formicarum sp. nov. and Dictyobacter arantiisoli sp. nov., belonging to the class Ktedonobacteria

“…Therefore, the ability to scavenge trace gas may be a common feature among several members of Ktedonobacteria. Additionally, numerous BGCs (13)(14)(15)(16)(17)(18)(19) for secondary metabolites mainly coding for non-ribosomal peptides, polyketides and ribosomally synthesized and post-translationally modified peptide products were predicted in the genomes of the seven strains (Tables 1 and S3), suggesting that, similarly to other ktedonobacterial strains [12], these strains have a high potential for producing secondary metabolites.…”

“…Several structurally novel compounds were discovered in Ts. hazakensis SK20-1 T [13,14]. Interestingly, some members of this class are expected to play an important role in energy cycling in volcanic and oligotrophic terrestrial environments as oxidizers of atmospheric CO and H 2 [15][16][17] Isolates and environmental DNA belonging to this class were found to be ubiquitous in various terrestrial environments and particularly abundant in several organic-poor soils of volcanic environments such as bare Antarctic soils [18], volcanic soils [19] and geothermally heated soils [20].…”

“…Several structurally novel compounds were discovered in Ts. hazakensis SK20-1 T [13, 14]. Interestingly, some members of this class are expected to play an important role in energy cycling in volcanic and oligotrophic terrestrial environments as oxidizers of atmospheric CO and H 2 [15–17]…”

Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them

“…Thermosporothrix hazakaensis SK20-1, isolated from a field-scale composter is the producer of sattabacin ( Figure 20 ) and hazakacin as well as indole thiazole containing molecules [ 446 , 447 ]. Related compounds 2′-oxosattabacin and ktedonoketone ( Figure 20 ) have been identified as the products of Thermosporothrix hazakensis NBRC 105916 [ 448 ]. Interestingly this genus belongs to the emerging bacterial class Ktedonobacteria, in the phylum Chloroflexi.…”

The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia

“…Myxococcota aside (it was recently proposed to re-classify this group that has traditionally been categorized as Myxobacteria, which are relatively well-studied for their NP-producing potential), [37][38][39] only a small number of NPs or associated BGCs have been identied from these phyla; a few are listed here. [40][41][42][43][44][45][46] If the assumption that both large genome sizes and understudied taxa represent increased potential to produce new NP scaffolds, this indicates that these 8 phyla (nearly double the number of phyla that have been at the focus of our eld since the 1940s) may Fig. 1 Earth's culturable microbiome has been the largest source of antibiotics used in the clinic.…”