Krüppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration

Moore, Darcie L.; Apara, Akintomide; Goldberg, Jeffrey L.

doi:10.1016/j.mcn.2011.05.005

Cited by 91 publications

(82 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, many of these studies have focused on the Krueppel-like factor (KLF) family of transcription factors, which have been shown to regulate the growth competency of RGCs and other CNS neurons 131–133 . Interestingly, examination of sequence similarity among KLF family members showed that those that share a high degree of sequence similarity also have similar effects on regeneration 131 .…”

Section: Transcriptional Changesmentioning

confidence: 99%

Intrinsic mechanisms of neuronal axon regeneration

2018

View full text Add to dashboard Cite

Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original targets. By contrast, injury to peripheral nerves is followed by robust regeneration, which can lead to recovery of sensory and motor functions. This regenerative response requires the induction of widespread transcriptional and epigenetic changes in injured neurons. Considerable progress has been made in recent years in understanding how peripheral axon injury elicits these widespread changes through the coordinated actions of transcription factors, epigenetic modifiers and, to a lesser extent, microRNAs. Although many questions remain about the interplay between these mechanisms, these new findings provide important insights into the pivotal role of coordinated gene expression and chromatin remodelling in the neuronal response to injury.

show abstract

Section: Transcriptional Changesmentioning

confidence: 99%

Intrinsic mechanisms of neuronal axon regeneration

2018

View full text Add to dashboard Cite

show abstract

“…There are seventeen KLF genes in mammals that group into three major subfamilies based on similarities in their N-terminal domains (Figure 1) [49]. Krüppel-like factors 3, 8, and 12 (Group 1) typically repress gene transcription by binding to the C-terminal binding proteins (CtBPs), a family of transcriptional repressors that recruit chromatin-modifying enzymes that add repressive marks to histones [80].…”

Section: 2 Krüppel-like Factorsmentioning

confidence: 99%

“…For example, KLF9 activates the Fgfr1 promoter in proliferating myoblasts but represses it in differentiated myotubes via the same DNA binding site [48]. Krüppel-like factors 5, 15 and 17 do not group into any of the other families based on the presence of identifiable protein-protein interaction motifs, although their primary amino acid sequences place KLFs 15 and 17 closer to Group 3, and KLF5 closer to Group 1 [47, 49]. All three can act as activators or repressors of transcription [25, 52, 82](and see section 3.3 ), In some cases, KLFs of the same subfamily have overlapping or redundant functions and can compensate for each other if one is lost or deleted [28, 85].…”

Section: 2 Krüppel-like Factorsmentioning

confidence: 99%

“…ChIP-seq experiments showed that all three factors shared many genomic binding sites, suggesting redundant regulation of target genes. Krüppel-like factors 2 and 4 are part of the same KLF subfamily and share common N-terminal domains; thus, it is not surprising that they would be able to compensate for each other [47, 49]. Interestingly, KLF5, which shares little sequence similarity outside of the DBD with other KLFs [49], can also compensate for loss of KLFs 2 and 4, which suggests additional robustness in this KLF-driven network.…”

Section: 1 Multiple Klfs Can Regulate Common Intracellular Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

Krüppel-like factors are effectors of nuclear receptor signaling

Knoedler

Denver

2014

General and Comparative Endocrinology

View full text Add to dashboard Cite

Binding of steroid and thyroid hormones to their cognate nuclear receptors (NRs) impacts virtually every aspect of postembryonic development, physiology and behavior, and inappropriate signaling by NRs may contribute to disease. While NRs regulate genes by direct binding to hormone response elements in the genome, their actions may depend on the activity of other transcription factors (TFs) that may or may not bind DNA. The Krüppel-like family of transcription factors (KLF) is an evolutionarily conserved class of DNA-binding proteins that influence many aspects of development and physiology. Several members of this family have been shown to play diverse roles in NR signaling. For example, KLFs 1) act as accessory transcription factors for NR actions, 2) regulate expression of NR genes, and 3) as gene products of primary NR response genes function as key players in NR-dependent transcriptional networks. In mouse models, deletion of different KLFs leads to aberrant transcriptional and physiological responses to hormones, underscoring the importance of these proteins in the regulation of hormonal signaling. Understanding the functional relationships between NRs and KLFs will yield important insights into mechanisms of NR signaling. In this review we present a conceptual framework for understanding how KLFs participate in NR signaling, and we provide examples of how these proteins function to effect hormone action.

show abstract

“…KLFs are highly distributed in various neural cells in the brain and have been implicated in a variety of human neurological diseases (Moore et al, 2009; Moore et al, 2011). Within this review, we will focus on recent advances describing the role and mechanisms of KLFs in neurological disorders, with a focus on ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Krüpple-like factors in the central nervous system: novel mediators in Stroke

et al. 2013

View full text Add to dashboard Cite

Transcription factors play an important role in the pathophysiology of many neurological disorders, including stroke. In the past three decades, an increasing number of transcription factors and their related gene signaling networks have been identified, and have become a research focus in the stroke field. Krüppel-like factors (KLFs) are members of the zinc finger family of transcription factors with diverse regulatory functions in cell growth, differentiation, proliferation, migration, apoptosis, metabolism, and inflammation. KLFs are also abundantly expressed in the brain where they serve as critical regulators of neuronal development and regeneration to maintain normal brain function. Dysregulation of KLFs has been linked to various neurological disorders. Recently, there is emerging evidence that suggests KLFs have an important role in the pathogenesis of stroke and provide endogenous vaso- or neuro- protection in the brain’s response to ischemic stimuli. In this review, we summarize the basic knowledge and advancement of these transcriptional mediators in the central nervous system, highlighting the novel roles of KLFs in stroke.

show abstract

Krüppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration

Cited by 91 publications

References 120 publications

Intrinsic mechanisms of neuronal axon regeneration

Intrinsic mechanisms of neuronal axon regeneration

Krüppel-like factors are effectors of nuclear receptor signaling

Krüpple-like factors in the central nervous system: novel mediators in Stroke

Contact Info

Product

Resources

About