Abstract:KLF8 is a zinc‐finger transcription factor known to play an essential role in cell cycle and differentiation. However, its physiological roles and functions in 3T3‐L1 cells remain relatively unclear. In the present study, we showed that KLF8 acts as a key regulator controlling adipocyte differentiation. In 3T3‐L1 preadipocytes, KLF8 expression was induced at an early stage of differentiation which was followed by expression of PPAR¥ã2 and C/EBP¥á. The mRNA level of KLF8 dramatically increased at 36 h and 48 h … Show more
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