Krüppel-like factor 4: A new potential biomarker of lung cancer

Fadous‑Khalifé, Marie Claude; Aloulou, Nijez; Jalbout, Majida; Hadchity, Joseph; Aftimos, Georges; Pâris, François; Hadchity, Élie

doi:10.3892/mco.2016.883

Cited by 32 publications

(39 citation statements)

References 26 publications

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“…This is the first study showing a significant difference in KLF4 protein and mRNA expression levels between normal and cancerous laryngeal tissues. Our findings were consistent with those reported by different studies showing a tumor suppressor role of KLF4 in several types of cancer, including gastric and colon cancers (6)(7)(8), bladder cancer (35), esophageal cancer (36), and non small cell lung carcinoma (14,37). Of note, in head and neck squamous cell carcinoma malignancies, KLF4 can exert different roles in different types.…”

Section: Discussionsupporting

confidence: 83%

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Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx

Karam

Fadous‑Khalifé

Tannous

et al. 2017

Molecular and Clinical Oncology

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Abstract. Late detection and lack of standard treatment strategies in larynx cancer patients result in high levels of mortality and poor prognosis. Prognostic stratification of larynx cancer patients based on molecular prognostic tumor biomarkers may lead to more efficient clinical management. Krüppel-like factor 4 (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis and are considered promising candidate biomarkers for various types of cancer. However, their role in larynx carcinoma remains to be elucidated. The present study aimed to determine KLF4 and HSP27 expression profiles in laryngeal tumors. The protein and mRNA expression levels of KLF4 and HSP27 were evaluated by immunohistochemical and reverse transcription-polymerase chain reaction analyses in 44 larynx carcinoma samples and 21 normal tissue samples, and then correlated with clinical characteristics. A differential expression of KLF4 and HSP27 was observed between normal and tumor tissues. The protein and mRNA expression levels of KLF4 were significantly decreased in larynx squamous cell carcinoma (LSCC) compared with normal tissue, whereas HSP27 was significantly overexpressed in tumor tissues compared with normal tissues, at the protein and mRNA levels. KLF4 expression decreased gradually with tumor progression whereas HSP27 expression increased. A significant difference was observed between stages I and IV. KLF4 and HSP27 exhibit opposite functions and roles in the carcinogenic process of LSCC. Their role in laryngeal cancer initiation and progression emphasizes their use as potential future targets for prognosis and treatment. KLF4 and HSP27 expression levels may act as potential biomarkers in patients with cancer of the larynx.

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Section: Discussionsupporting

confidence: 83%

“…In head and neck squamous cell carcinoma (HNSCC) tissues, persistent KLF4 expression predicts poor prognosis and confers aggressiveness (13). Recent studies showed that KLF4 is upregulated in small cell lung carcinoma tissues and has a potential tumor-promoting role in this type of lung malignancy (14).…”

Section: Introductionmentioning

confidence: 99%

Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx

Karam

Fadous‑Khalifé

Tannous

et al. 2017

Molecular and Clinical Oncology

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“…Fadous-Khalifé et al (25) demonstrated that, compared with normal tissue, the expression of Kruppel-like factor 4 (KLF4) was markedly decreased in non-small cell lung cancer, although it was overexpressed in small cell lung cancer. In addition, Perini et al (26) demonstrated that the overexpression of membrane epidermal growth factor receptor is associated with decreased survival in pancreas cancer tissue.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic effect of serum miR-196b as biomarker in colorectal cancer

2016

Biomedical Reports

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The microRNA, miR-196b, serves a role in normal cell differentiation, proliferation and tumorigenesis of different types of cancer. The aim of the present study was to explore the serum expression of miR-196b in colorectal cancer (CRC) and its correlation with clinicopathological features. Sera samples were obtained from 103 patients with CRC, 51 patients with colorectal adenoma (Ad) and 100 healthy individuals for the present study. The serum expression of miR-196b in sera samples of the three cohorts was detected using reverse transcription-quantitative polymerase chain reaction. The diagnostic value of miR-196b in the serum of the patients with CRC was evaluated by receiver operating characteristic (ROC) curve and survival analysis, using the Kaplan-Meier method, which was performed with the data from a 5-year follow-up. The expression of miR-196b in the serum of patients with CRC was significantly higher compared with that in Ad patients or healthy individuals (all P<0.001), and the overexpression of serum miR-196b was clearly associated with lymph node invasion, differentiation, and the tumor-lymph nodes-metastasis stage (all P<0.05). ROC curve analysis demonstrated that, comparing patients with CRC with healthy individuals, the area under the curve of serum miR-196b was 0.8135, and its specificity and sensitivity were 63 and 87.38%, respectively, at a diagnostic threshold of −4.785. Patients with CRC of miR-196b-high status had shorter overall survival and disease-free survival rates compared with those of miR-196b-low status. In conclusion, the results of the present study demonstrated that serum miR-196b is upregulated in CRC, and may have an application as a diagnostic and prognostic biomarker for patients with CRC.

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“…In one study, the expression of KLF4 is downregulated in the majority of primary lung cancers examined, and ectopic expression of KLF4 suppresses lung cancer cell proliferation and clonogenic formation in vitro , and suppresses tumor growth in vivo (127,128). A recent study showed differential expression of KLF4 in lung cancer, where a significant decrease in KLF4 expression is observed in non-small-cell lung cancer compared with that in normal tissue, while a significant overexpression is detected in small-cell lung cancer (129). …”

Section: Roles In Diseasesmentioning

confidence: 99%

Krüppel-like factor 4 (KLF4): What we currently know

Ghaleb

Yang

2017

Gene

416

349

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Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, after it was shown in 2006 as one of four factors required for the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge on the different functions and roles of KLF4 in various tissue and organ systems.

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Krüppel-like factor 4: A new potential biomarker of lung cancer

Cited by 32 publications

References 26 publications

Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx

Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx

The diagnostic effect of serum miR-196b as biomarker in colorectal cancer

Krüppel-like factor 4 (KLF4): What we currently know

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