Krüppel-like Factor 2 (KLF2) in Immune Cell Migration

Wittner, Jens; Schuh, Wolfgang

doi:10.3390/vaccines9101171

Cited by 24 publications

(17 citation statements)

References 104 publications

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“…KLF2 (Krüppel-like factor 2) belongs to the Krüppel-like family of ZNF transcription factors and bears a Cys 2 His 2 ZNF-containing DNA binding domain. KLF2 is a key regulator of activation, differentiation, and migration processes in numerous cell types, including endothelial cells function and vascular homeostasis [ 98 ].…”

Section: Roles Of Host Znf Proteins In Covid-19mentioning

confidence: 99%

Host and Viral Zinc-Finger Proteins in COVID-19

Esposito

D’Abrosca

Antolak

et al. 2022

IJMS

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An unprecedented effort to tackle the ongoing COVID-19 pandemic has characterized the activity of the global scientific community over the last two years. Hundreds of published studies have focused on the comprehension of the immune response to the virus and on the definition of the functional role of SARS-CoV-2 proteins. Proteins containing zinc fingers, both belonging to SARS-CoV-2 or to the host, play critical roles in COVID-19 participating in antiviral defenses and regulation of viral life cycle. Differentially expressed zinc finger proteins and their distinct activities could thus be important in determining the severity of the disease and represent important targets for drug development. Therefore, we here review the mechanisms of action of host and viral zinc finger proteins in COVID-19 as a contribution to the comprehension of the disease and also highlight strategies for therapeutic developments.

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Section: Roles Of Host Znf Proteins In Covid-19mentioning

confidence: 99%

Host and Viral Zinc-Finger Proteins in COVID-19

Esposito

D’Abrosca

Antolak

et al. 2022

IJMS

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“…Of note, Klf2 seems to have oncogenic potential in our experimental model, being this report the first connection between this gene and sarcoma biology. Furthermore, KLF2, as an ERK5 downstream target, could be implicated in cancer through different mechanisms that remain unexplored, as could be the case of stem cell biology [ 65 , 66 ] or other processes such as inflammatory response [ 67 ], immune response [ 68 ], or angiogenesis [ 61 , 69 ]. Therefore, one possibility could be that the ERK5–KLF2 axis acts as a node in sarcoma biology by controlling several key processes.…”

Section: Discussionmentioning

confidence: 99%

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

Arconada-Luque

Jiménez-Suarez

Pascual-Serra

et al. 2022

Cancers

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Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, showing an increased expression of ERK5. Indeed, this upregulation was also observed in human sarcomas of muscular origin, such as leiomyosarcoma or rhabdomyosarcoma. Moreover, in cell lines derived from these 3MC-induced tumors, abrogation of Mapk7 expression by using specific shRNAs decreased in vitro growth and colony-forming capacity and led to a marked loss of tumor growth in vivo. In fact, transcriptomic profiling in ERK5 abrogated cell lines by RNAseq showed a deregulated gene expression pattern for key biological processes such as angiogenesis, migration, motility, etc., correlating with a better prognostic in human pathology. Finally, among the various differentially expressed genes, Klf2 is a key mediator of the biological effects of ERK5 as indicated by its specific interference, demonstrating that the ERK5–KLF2 axis is an important determinant of sarcoma biology that should be further studied in human pathology.

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“…KLF2 and KLF4 are assumed to play a central role in maintaining endothelial cell homeostasis and vascular health. Multiple studies have confirmed the atheroprotective effect of KLF2 and KLF4 through inhibition of inflammatory response [ 48 , 49 , 50 , 51 , 52 ]. The activator of KLF2 presented anti-inflammatory effects and attenuated the adhesion of monocytes to endothelial cells, which could be a promising therapeutic strategy for atherosclerosis [ 53 ].…”

Section: Zinc-related Proteinsmentioning

confidence: 99%

Investigating the Role of Zinc in Atherosclerosis: A Review

et al. 2022

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Zinc, an indispensable micronutrient for human health, might play an important role in the development of atherosclerosis. Zinc could be involved in the atherogenic process through interaction with atherogenic cells, such as endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and immune cells. In addition, zinc also exerts important positive or negative functions in various atherosclerosis-related risk factors, including lipid metabolism, glucose metabolism, and blood pressure. Currently, evidence focusing on the relationship between zinc status and atherogenic risk factors has been well established, while the direct interaction between zinc and atherosclerosis has not been fully understood. In this review, we aimed to summarize the association between zinc and atherosclerosis and explore current findings on how zinc and zinc homeostasis-associated proteins act in the atherogenic processes.

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Krüppel-like Factor 2 (KLF2) in Immune Cell Migration

Cited by 24 publications

References 104 publications

Host and Viral Zinc-Finger Proteins in COVID-19

Host and Viral Zinc-Finger Proteins in COVID-19

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

Investigating the Role of Zinc in Atherosclerosis: A Review

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