2000
DOI: 10.1046/j.1440-1681.2000.03237.x
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Krn2391: Dual Action On Rat Pulmonary Artery And No Loss Of Potency In Pulmonary Hypertension

Abstract: 1. The pulmonary vasorelaxant properties of KRN2391 (N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide) were examined in isolated ring preparations of main (MPA) and intralobar (IPA) pulmonary artery from control and pulmonary hypertensive rats (exposure to hypoxia, 10% oxygen, for 1 week). 2. On both MPA and IPA, pulmonary vasorelaxant responses were inhibited by methylene blue (10 micromol/L) or glibenclamide (1 or 10 micromol/L). Thus, KRN2391 has the properties of both a nitric oxide (NO) donor and a K… Show more

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“…Cromakalim, a well-characterized selective K ATP channel opener that has been exploited pharmacologically to induce hyperpolarization and thus vasodilatation in conditions such as pulmonary hypoxia [2], has yet to be assessed in human placental blood vessels. KRN2391 is a putative K ATP channel opener that has been suggested to produce significant relaxation of rat [15] and human [16] systemic arterial preparations. KRN2391 has also been suggested to have dual modes of action; a K ATP channel opener and an organic nitrate [17,18] and, thus, may provide a more potent tool for placental vascular relaxation.…”
Section: Introductionmentioning
confidence: 99%
“…Cromakalim, a well-characterized selective K ATP channel opener that has been exploited pharmacologically to induce hyperpolarization and thus vasodilatation in conditions such as pulmonary hypoxia [2], has yet to be assessed in human placental blood vessels. KRN2391 is a putative K ATP channel opener that has been suggested to produce significant relaxation of rat [15] and human [16] systemic arterial preparations. KRN2391 has also been suggested to have dual modes of action; a K ATP channel opener and an organic nitrate [17,18] and, thus, may provide a more potent tool for placental vascular relaxation.…”
Section: Introductionmentioning
confidence: 99%