Krill oil ameliorates benign prostatic hyperplasia by regulating G
1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers
Hoon Kim,
Jongyeob Kim,
Byungdoo Hwang
et al.
Abstract:Krill oil (KO) exhibits various biological activities, such as anti-inflammatory and antitumor effects. However, the inhibitory effects of benign prostatic hyperplasia (BPH) in vitro and in vivo have not yet been studied. This study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis method. KO treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G 0 /G 1 phase arrest through the modulation of positive and negative regulators in both prostate cell types. KO t… Show more
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