Kreislaufstörungen und Gefäßprozesse des Rückenmarks

Erythropoietin preconditioning improves clinical and histologic outcome in an acute spinal cord ischemia and reperfusion rabbit model

“…24 After 96 hours, we only found intact neurons or infarcted areas that are mainly located in central regions of the spinal cord (Fig 2 ), which is in agreement with the literature. 25 The histologic evaluation showed significantly more surviving neurons in the rhEPO group at level L3 and a clear trend at levels L1 and L2. Neurons of the thoracic and the thoracolumbar part of the spinal cord were completely unaffected in all three groups and confirmed correct clamping procedure.…”

Spinaler Infarkt

“…2), getroffen werden [2]. Chronische venöse Mikrozirkulationsstörungen können sich allerdings auch durch eine akute Symptomatik klinisch manifestieren [1,3,4,5]. Neben der venösen Kongestion einschließ-lich Thrombosierungen und Hämorrha-gien kann auch ein Stealphänomen z.…”

Vascular Events After Spinal Cord Injury: Contribution to Secondary Pathogenesis

“…35 Thus, the vessels on the surface of the spinal cord are relatively spared from initial insult, whereas the microvasculature in the gray matter is subjected to stretching and shear stress, a consequence of the difference in compliance between the gray and white matter. 37 The immediate mechanical damage to gray matter microvasculature impairs the microcirculation and impedes perfusion, 38,39 leading to a profound reduction of spinal cord blood 40,41 accompanied by impairment of autoregulation. 40 The impaired blood flow in the traumatized spinal cord may be further compromised by systemic responses, including posttraumatic hypotension, bradycardia, and decreased cardiac output, that exacerbate the ischemic damage.…”