KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis
Ashley N. Sigafoos,
Ezequiel J. Tolosa,
Ryan M. Carr
et al.
Abstract:Aberrant activation of GLI transcription factors has been implicated in the pathogenesis of different tumor types including pancreatic ductal adenocarcinoma (PDAC). However, the mechanistic link with established drivers of this disease remains in part elusive. Here, using a new genetically-engineered mouse model overexpressing constitutively active mouse form of GLI2 and a combination of genome wide assays, we provide evidence of a novel mechanism underlying the interplay between KRAS, a major driver of PDAC d… Show more
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