KRAS Inhibitors and Target Engagement Technology: From Undruggable to Druggable Targets in Cancer Therapeutics

Abstract

Disease Area. Cancer Biological Target. RAS proteins (KRAS G12C mutant) Summary. Cancer is the second leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths ["Cancer", who.int fact sheet), assessed 3/20/2022]. Cancer is simply an abnormal and rapid growth of cells that permeate beyond regular cell dimensions and can develop in any part of the body. Furthermore, cancer-causing infections, such as hepatitis and human papillomavirus (HPV), are the cause of approximately 30% of cancer cases in low-and lower-income countries. However, many cancers can be cured if detected early and treated effectively.Protein−protein interactions (PPIs) are important for basically all biological processes and constitute more than 0.5 million estimated interactions in humans. The rat sarcoma viral oncogene homologue (Ras) proteins are part of the family of small GTPases that are activated by growth factors and

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