KPC-Producing Extreme Drug-Resistant Klebsiella pneumoniae Isolate from a Patient with Diabetes Mellitus and Chronic Renal Failure on Hemodialysis in South Korea

Identification of Capsular Types in Carbapenem-Resistant Klebsiella pneumoniae Strains by wzc Sequencing and Implications for Capsule Depolymerase Treatment

“…Previous studies reported that ST258 is a major clone throughout the world (23,24,52), and a single-locus variant of ST258, ST11, was considered to be predominant in ESBL-producing strains in Asia (53,54) and was prevalent in CRKP strains in Taiwan (55). In the current study, ST11 was the major ST of these CRKP strains (40/85 strains [47%]), whereas other STs each accounted for less than 10% of CRKP strains.…”

First Outbreak of KPC-2-Producing Klebsiella pneumoniae Sequence Type 258 in a Hospital in South Korea

“…MLST of the three bla KPC-2 -producing isolates resulted in one sequence type (ST), 258 (allelic profile 3-3-1-1-1-1-79), but the type of the control strain was ST11 (allelic profile 3-3-1-1-1-1-4). Although the MLST types of the first South Korean case of KPC-2-producing K. pneumoniae and our control strain were ST11, the remaining isolates were ST258 (3)(4)(5). The bla KPC-2 gene-carrying K. pneumoniae ST258 clone has been identified worldwide, suggesting that it may have contributed significantly to the spread of bla KPC-2 genes (1).…”

“…Thereafter, KPC-2 and its variant producers have caused severe treatment problems in hospitals around New York and have also been reported in Europe, South America, and China (1). In South Korea, only two cases of infection with KPC-2-producing K. pneumoniae had been reported by 2010 (3,4). Subsequently, six bla KPC-2 -positive K. pneumoniae strains were sporadically isolated from several hospitals during nationwide surveillance in 2011 (5).…”

Dissemination of bla KPC-2 by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae Species in Brazil

“…The ST258 clone is now globally spread and is mostly associated with the emergence and dissemination of KPC producers in different countries of North America, Europe, and Asia (2,3,14,16,20,25,26,34). The ST11-K. pneumoniae lineage, first reported in France in 1997, is currently predominant in China, South Korea, and Hungary and has also been detected in the Netherlands, Norway, Poland, Portugal, Spain, and Brazil (2,9,17,27,30,32,35,37; Luísa Peixe, personal communication). This clone has been extensively associated with different extended-spectrum beta-lactamases (ESBLs), mainly CTX-M-15 and CTX-M-14 (17,27,37) and more recently the KPC-2 (2,30,34) and VIM enzymes (18).…”