KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of pancreatic cancer
Daniele Pereira Ferrari,
Fernanda Ramos-Gomes,
Frauke Alves
et al.
Abstract:Mouse models for the study of pancreatic ductal adenocarcinoma (PDAC) are well-established and representative of many key features observed in human PDAC. To monitor tumor growth, cancer cells that are implanted in mice are often transfected with reporter genes, such as firefly luciferase (Luc), enabling in vivo optical imaging over time. Since Luc can induce an immune response, we aimed to evaluate whether the expression of Luc could affect the growth of KPC tumors in mice by inducing immunogenicity. Although… Show more
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