Kounis syndrome

Ntuli, Pat Mahungwane; Makambwa, Edson

doi:10.7196/samjnew.8767

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…According to a study done in South Africa, they report the case of an HIV-negative 39-year-old man with no coronary risk factors or family history of premature coronary artery disease, who developed Kounis syndrome after the administration of fluoroquinolone for dysuria [4]. Tajda present a case of male who suffered attacks of dyspnoea, hypoxemia, hypotension, purple-red skin, and chest pain over several years.…”

Section: Discussionmentioning

confidence: 99%

Kounis Syndrome - A Retrospective Post-Mortem Study

Kumar¹

2017

IJFSC

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Kounis syndrome is defined as acute coronary syndrome caused by an allergic reaction or a strong immune reaction to a drug or any other substance. Mast cell activation and release of inflammatory cytokines from the reaction leads to spasm of the artery leading to the heart muscle or a plaque breaking free and blocking that artery. In this study, all the suspected cases of drug anaphylaxis which are autopsied during the period January 2011 to December 2014 were analyzed at the Department of Forensic Medicine & Toxicology, AIMS, BG Nagar, and Karnataka. The incidence, age and sex wise distribution of cases and histopathology reports were analyzed. In 6 cases histo-pathology report shows 80 to 90% block in coronaries with ruptured atheromatous plaques, cardiac muscle hypertrophy in heart, atheromatous plaques in aorta and hemorrhagic infarct, areas of intra-alveolar hemorrhage, pulmonary edema, focal areas shows histiocytes, cholesterol bodies. On examination of skin in and around the injection site using color tests, thin layer chromatography, high performance thin layer chromatographic methods at regional forensic science laboratory, 2 cases have responded for diclofenac compound and 3 cases have responded for traces of ceftriaxone compound and nothing was detected in remaining 2 cases.

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Section: Discussionmentioning

confidence: 99%

Kounis Syndrome - A Retrospective Post-Mortem Study

Kumar¹

2017

IJFSC

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“…Diagnostic criteria. Kounis syndrome should be suspected in young and healthy patients who are not presumed to have atherosclerosis and who are presenting with ACS [32]. In order to establish a positive diagnosis, the patient must present with a systemic allergic reaction accompanied by myocardial ischemia demonstrated by the characteristic electrocardiographic, laboratory, ultrasound, and angiographic findings [29].…”

Section: Kounis Syndromementioning

confidence: 99%

“…Caution must be given to betablockers, which can worsen the vasospasm, as well as to adrenaline, which would otherwise be the gold standard of treatment but exacerbates the ischemia and can intensify the Diagnostic criteria. Kounis syndrome should be suspected in young and healthy patients who are not presumed to have atherosclerosis and who are presenting with ACS [32]. In order to establish a positive diagnosis, the patient must present with a systemic allergic reaction accompanied by myocardial ischemia demonstrated by the characteristic electrocardiographic, laboratory, ultrasound, and angiographic findings [29].…”

Section: Kounis Syndromementioning

confidence: 99%

Broad Electrocardiogram Syndromes Spectrum: From Common Emergencies to Particular Electrical Heart Disorders

Balta

Ceasovschih

Șorodoc

et al. 2022

JPM

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Electrocardiogram (ECG) still remains a very useful diagnostic method in modern cardiology. Its broad availability, noninvasiveness and good sensitivity explain why it plays a capital role in the very beginning of the process of diagnosis for every patient, with or without cardiac-related complaints. For the practitioner, good training in ECG interpretation is mandatory. Sometimes, the ECG trace reveals particular aspects that may cause confusion and complicate decision-making. In this article, we present several less common situations underlying the general context and ECG features. The syndromes studied have a high pathological significance and may range from acute emergencies that call for a rapid therapeutical response to chronic syndromes that require prolonged observation, monitoring and risk stratification.

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“…Researchers have described three variants of KS: ACS with or without troponin release resulting from co ronary vasospasm (type I); ACS among patients with pre-existing coronary artery disease (CAD) ca used by atheromatous plaque erosion or rupture (type II); and ACS secondary to coronary artery thrombosis, including coronary artery stent thrombosis (type III). [4,5] Type III KS is subdivided to type IIIa that includes stent thrombosis and type IIIb that includes stent restenosis. [6] KS can be caused by all kinds of seafood, such as finned fish, molluscan shellfish, cephalopods, and crustacean shellfi sh.…”

Section: Dear Editormentioning

confidence: 99%